C1orf122
Uncharacterized protein C1orf122
Also known as: CA122_HUMAN, FLJ45459
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZSJ8
- Gene
- C1orf122
- Ensembl
- ENSG00000197982
- Chromosome
- 1
- Canonical length
- 110 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for C1orf122 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
110 residues, UniProt reviewed canonical sequence.
>Q6ZSJ8|C1orf122
1 MEWGPGSDWS RGEAAGVDRG KAGLGLGGRP PPQPPREERA QQLLDAVEQR QRQLLDTIAA
61 CEEMLRQLGR RRPEPAGGGN VSAKPGAPPQ PAVSARGGFP KDAGDGAAEPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C1orf122 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 171 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 171 nTPM
- midbrain: 156 nTPM
- amygdala: 136 nTPM
- hippocampal formation: 120 nTPM
- basal ganglia: 112 nTPM
- cerebral cortex: 110 nTPM
Single-cell type
- epididymal principal cells: 352 nCPM
- hepatic stellate cells: 213 nCPM
- esophageal apical cells: 205 nCPM
- hofbauer cells: 175 nCPM
- breast lactating cells: 163 nCPM
- esophageal suprabasal cells: 159 nCPM
Immune cell
- eosinophil: 5.8 nTPM
- intermediate monocyte: 5.8 nTPM
- non-classical monocyte: 5.6 nTPM
- classical monocyte: 4.9 nTPM
- gdT-cell: 3.7 nTPM
- myeloid DC: 3.6 nTPM
Brain region
- white matter: 101 nTPM
- medulla oblongata: 96 nTPM
- thalamus: 91 nTPM
- spinal cord: 89 nTPM
- basal ganglia: 86 nTPM
- cerebellum: 86 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.76
- gnomAD pLI
- 0.14
- gnomAD missense Z
- 0.43
- DepMap mean gene effect
- -0.26
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4726
- Domain of unknown function (DUF4726)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of C1orf122 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C1orf122 as an antibody target. Whether an autoantibody or antibody against C1orf122 could matter depends on whether native C1orf122 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C1orf122 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C1orf122 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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