Seroatlas · Human Serome Atlas

TXLNB

Beta-taxilin

Also known as: C6orf198, dJ522B19.2, DKFZp451A175, MDP77, TXLNB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3L3
Gene: TXLNB
Ensembl: ENSG00000164440
Chromosome: 6
Canonical length: 684 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable syntaxin binding activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

684 residues, UniProt reviewed canonical sequence.

>Q8N3L3|TXLNB
     1  MEANHSEQLS AERQSTPPGD SSSLPSHNGL EKEDGQDSPT PVQPPEKEAS VHPDISEELN
    61  RQLEDIINTY GSAASTAGKE GSARASEQPE NAESPDNEDG DCEETTEEAG REPVASGEPP
   121  TVKEPVSNKE QKLEKKILKG LGKEANLLMQ NLNKLQTPEE KFDFLFKKYA ELLDEHRTEQ
   181  KKLKLLQKKQ VQIQKEKDQL QGEHSRAILA RSKLESLCRE LQRHNKTLKE EALQRAREEE
   241  EKRKEITSHF QSTLTDIQGQ IEQQSERNMK LCQENTELAE KLKSIIDQYE LREEHLDKIF
   301  KHRELQQKLV DAKLEQAQEM MKEAEERHKR EKEYLLNQAA EWKLQAKVLK EQETVLQAQL
   361  TLYSGRFEEF QSTLTKSNEV FATFKQEMDK TTKKMKKLEK DTATWKARFE NCNKALLDMI
   421  EEKALRAKEY ECFVMKIGRL ENLCRALQEE RNELHKKIRD AEISEKDDQS QHNSDEEPES
   481  NVSVDQEIDA EEVNSVQTAV KNLATAFMII HHPESTPHQS KETQPEIGSS QESADAALKE
   541  PEQPPLIPSR DSESPLPPLT PQAEAEGGSD AEPPSKASNS PAGLGAETQC EGLPVGAQAD
   601  QASWKPEAEA SGQAPQAPTE ASLQKMEADV PAPACAAEEH VAAMVPACEP SRQPPRAAAE
   661  ELPVGASAGP QPRNVADTNL EGVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXLNB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 281 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 281 nTPM
tongue: 177 nTPM
heart muscle: 77 nTPM
ovary: 8.2 nTPM
thymus: 7.2 nTPM
esophagus: 4.1 nTPM

Single-cell type

myonuclei: 195 nCPM
thymic myoid cells: 132 nCPM
late spermatids: 57 nCPM
cardiomyocytes: 54 nCPM
early spermatids: 19 nCPM
late primary spermatocytes: 11 nCPM

Immune cell

memory B-cell: 1.9 nTPM
naive B-cell: 0.8 nTPM
neutrophil: 0.7 nTPM
memory CD8 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

spinal cord: 4.8 nTPM
medulla oblongata: 4.4 nTPM
white matter: 4.4 nTPM
hypothalamus: 3.8 nTPM
hippocampal formation: 3.1 nTPM
midbrain: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: -0.64
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

syntaxin binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TXLNB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXLNB as an antibody target. Whether an autoantibody or antibody against TXLNB could matter depends on whether native TXLNB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXLNB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXLNB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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