Seroatlas · Human Serome Atlas

KDM4D

Lysine-specific demethylase 4D

Also known as: FLJ10251, JMJD2D, KDM4D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6B0I6
Gene
KDM4D
Ensembl
ENSG00000186280
Chromosome
11
Canonical length
523 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables histone H3K9me2/H3K9me3 demethylase activity. Involved in inflammatory response. Acts upstream of or within several processes, including cellular response to ionizing radiation; double-strand break repair via homologous recombination; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q6B0I6|KDM4D
     1  METMKSKANC AQNPNCNIMI FHPTKEEFND FDKYIAYMES QGAHRAGLAK IIPPKEWKAR
    61  ETYDNISEIL IATPLQQVAS GRAGVFTQYH KKKKAMTVGE YRHLANSKKY QTPPHQNFED
   121  LERKYWKNRI YNSPIYGADI SGSLFDENTK QWNLGHLGTI QDLLEKECGV VIEGVNTPYL
   181  YFGMWKTTFA WHTEDMDLYS INYLHLGEPK TWYVVPPEHG QRLERLAREL FPGSSRGCGA
   241  FLRHKVALIS PTVLKENGIP FNRITQEAGE FMVTFPYGYH AGFNHGFNCA EAINFATPRW
   301  IDYGKMASQC SCGEARVTFS MDAFVRILQP ERYDLWKRGQ DRAVVDHMEP RVPASQELST
   361  QKEVQLPRRA ALGLRQLPSH WARHSPWPMA ARSGTRCHTL VCSSLPRRSA VSGTATQPRA
   421  AAVHSSKKPS STPSSTPGPS AQIIHPSNGR RGRGRPPQKL RAQELTLQTP AKRPLLAGTT
   481  CTASGPEPEP LPEDGALMDK PVPLSPGLQH PVKASGCSWA PVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KDM4D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • testis: 31 nTPM
  • retina: 1.9 nTPM
  • fallopian tube: 0.9 nTPM
  • heart muscle: 0.9 nTPM
  • ovary: 0.9 nTPM
  • parathyroid gland: 0.9 nTPM

Single-cell type

  • late primary spermatocytes: 245 nCPM
  • early spermatids: 92 nCPM
  • late spermatids: 55 nCPM
  • early primary spermatocytes: 41 nCPM
  • sertoli cells: 31 nCPM
  • differentiating spermatogonia: 21 nCPM

Immune cell

  • non-classical monocyte: 2.2 nTPM
  • T-reg: 0.6 nTPM
  • memory B-cell: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM

Brain region

  • spinal cord: 1.3 nTPM
  • white matter: 1.2 nTPM
  • basal ganglia: 1.1 nTPM
  • cerebellum: 1.1 nTPM
  • hypothalamus: 1.1 nTPM
  • medulla oblongata: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.61
gnomAD pLI
0.43
gnomAD missense Z
2.16
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KDM4D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KDM4D as an antibody target. Whether an autoantibody or antibody against KDM4D could matter depends on whether native KDM4D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KDM4D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KDM4D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KDM4D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...