Seroatlas · Human Serome Atlas

BCL2L14

Apoptosis facilitator Bcl-2-like protein 14

Also known as: B2L14_HUMAN, BCL-G, BCLG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZR8
Gene: BCL2L14
Ensembl: ENSG00000121380
Chromosome: 12
Canonical length: 327 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q9BZR8|BCL2L14
     1  MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT RSLSQRGLGN
    61  CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV EKEDSQSTPA KVSAQGQRTL
   121  EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV ISIANRVAEI VYSWPPPQAT QAGGFKSKEI
   181  FVTEGLSFQL QGHVPVASSS KKDEEEQILA KIVELLKYSG DQLERKLKKD KALMGHFQDG
   241  LSYSVFKTIT DQVLMGVDPR GESEVKAQGF KAALVIDVTA KLTAIDNHPM NRVLGFGTKY
   301  LKENFSPWIQ QHGGWEKILG ISHEEVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL2L14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
rectum: 15 nTPM
duodenum: 13 nTPM
small intestine: 12 nTPM
colon: 10 nTPM
stomach: 8.8 nTPM

Single-cell type

late spermatids: 276 nCPM
early spermatids: 86 nCPM
oligodendrocytes: 48 nCPM
oligodendrocyte progenitor cells: 44 nCPM
late primary spermatocytes: 40 nCPM
loop of henle epithelial cells: 40 nCPM

Immune cell

T-reg: 0.7 nTPM
memory CD4 T-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 1.3 nTPM
amygdala: 1.2 nTPM
hippocampal formation: 1.2 nTPM
medulla oblongata: 1.2 nTPM
choroid plexus: 1.1 nTPM
basal ganglia: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL2L14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL2L14 as an antibody target. Whether an autoantibody or antibody against BCL2L14 could matter depends on whether native BCL2L14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL2L14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL2L14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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