Seroatlas · Human Serome Atlas

THOC1

THO complex subunit 1

Also known as: HPR1, P84, THOC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FV9
Gene
THOC1
Ensembl
ENSG00000079134
Chromosome
18
Canonical length
657 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA binding activity and RNA binding activity. Involved in mRNA export from nucleus. Located in chromosome, telomeric region; cytoplasm; and nuclear speck. Part of THO complex part of transcription export complex. Implicated in autosomal dominant nonsyndromic deafness 86. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>Q96FV9|THOC1
     1  MSPTPPLFSL PEARTRFTKS TREALNNKNI KPLLSTFSQV PGSENEKKCT LDQAFRGILE
    61  EEIINHSSCE NVLAIISLAI GGVTEGICTA STPFVLLGDV LDCLPLDQCD TIFTFVEKNV
   121  ATWKSNTFYS AGKNYLLRMC NDLLRRLSKS QNTVFCGRIQ LFLARLFPLS EKSGLNLQSQ
   181  FNLENVTVFN TNEQESTLGQ KHTEDREEGM DVEEGEMGDE EAPTTCSIPI DYNLYRKFWS
   241  LQDYFRNPVQ CYEKISWKTF LKYSEEVLAV FKSYKLDDTQ ASRKKMEELK TGGEHVYFAK
   301  FLTSEKLMDL QLSDSNFRRH ILLQYLILFQ YLKGQVKFKS SNYVLTDEQS LWIEDTTKSV
   361  YQLLSENPPD GERFSKMVEH ILNTEENWNS WKNEGCPSFV KERTSDTKPT RIIRKRTAPE
   421  DFLGKGPTKK ILMGNEELTR LWNLCPDNME ACKSETREHM PTLEEFFEEA IEQADPENMV
   481  ENEYKAVNNS NYGWRALRLL ARRSPHFFQP TNQQFKSLPE YLENMVIKLA KELPPPSEEI
   541  KTGEDEDEED NDALLKENES PDVRRDKPVT GEQIEVFANK LGEQWKILAP YLEMKDSEIR
   601  QIECDSEDMK MRAKQLLVAW QDQEGVHATP ENLINALNKS GLSDLAESLT NDNETNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THOC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • testis: 16 nTPM
  • thymus: 12 nTPM
  • lymph node: 11 nTPM
  • tonsil: 11 nTPM
  • choroid plexus: 9.9 nTPM
  • liver: 9.3 nTPM

Single-cell type

  • somatotrophs: 158 nCPM
  • erythrocyte progenitors: 137 nCPM
  • early primary spermatocytes: 127 nCPM
  • lactotrophs: 120 nCPM
  • late primary spermatocytes: 118 nCPM
  • myonuclei: 113 nCPM

Immune cell

  • MAIT T-cell: 15 nTPM
  • basophil: 14 nTPM
  • naive CD4 T-cell: 14 nTPM
  • memory B-cell: 13 nTPM
  • naive CD8 T-cell: 13 nTPM
  • T-reg: 13 nTPM

Brain region

  • white matter: 9.1 nTPM
  • pons: 7.7 nTPM
  • medulla oblongata: 7.6 nTPM
  • cerebral cortex: 7.5 nTPM
  • basal ganglia: 7.1 nTPM
  • cerebellum: 7.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about THOC1.

Disease | AllUniProt

Conditions THOC1 is implicated in, by any mechanism.

  • Deafness, autosomal dominant, 86 (DFNA86) MIM:620280

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 75 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hearing loss, autosomal dominant 86

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
2.58
DepMap mean gene effect
-1.16
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THOC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THOC1 as an antibody target. Whether an autoantibody or antibody against THOC1 could matter depends on whether native THOC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THOC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THOC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THOC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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