Seroatlas · Human Serome Atlas

THOC7

THO complex subunit 7

Also known as: FLJ23445, fSAP24, NIF3L1BP1, THOC7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6I9Y2
Gene: THOC7
Ensembl: ENSG00000163634
Chromosome: 3
Canonical length: 204 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Predicted to enable RNA binding activity. Involved in mRNA export from nucleus. Located in chromosome, telomeric region; cytosol; and nuclear speck. Part of THO complex part of transcription export complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q6I9Y2|THOC7
     1  MGAVTDDEVI RKRLLIDGDG AGDDRRINLL VKSFIKWCNS GSQEEGYSQY QRMLSTLSQC
    61  EFSMGKTLLV YDMNLREMEN YEKIYKEIEC SIAGAHEKIA ECKKQILQAK RIRKNRQEYD
   121  ALAKVIQHHP DRHETLKELE ALGKELEHLS HIKESVEDKL ELRRKQFHVL LSTIHELQQT
   181  LENDEKLSEV EEAQEASMET DPKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THOC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 109 nTPM
tongue: 97 nTPM
amygdala: 86 nTPM
heart muscle: 82 nTPM
hippocampal formation: 80 nTPM
cerebral cortex: 79 nTPM

Single-cell type

esophageal suprabasal cells: 350 nCPM
megakaryocytes: 328 nCPM
esophageal basal cells: 311 nCPM
esophageal apical cells: 275 nCPM
syncytiotrophoblasts: 256 nCPM
late primary spermatocytes: 241 nCPM

Immune cell

basophil: 73 nTPM
T-reg: 62 nTPM
myeloid DC: 59 nTPM
NK-cell: 56 nTPM
plasmacytoid DC: 54 nTPM
MAIT T-cell: 54 nTPM

Brain region

cerebral cortex: 42 nTPM
hippocampal formation: 41 nTPM
white matter: 40 nTPM
basal ganglia: 38 nTPM
midbrain: 38 nTPM
hypothalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.01
gnomAD missense Z: 1.09
DepMap mean gene effect: -1.08
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

THO complex subunit 7/Mft1
Tho complex subunit 7

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THOC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THOC7 as an antibody target. Whether an autoantibody or antibody against THOC7 could matter depends on whether native THOC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THOC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THOC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...