Seroatlas · Human Serome Atlas

THOC2

THO complex subunit 2

Also known as: CXorf3, dJ506G2.1, MRX12, MRX35, THO2, THOC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NI27
Gene
THOC2
Ensembl
ENSG00000125676
Chromosome
X
Canonical length
1593 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

1593 residues, UniProt reviewed canonical sequence.

>Q8NI27|THOC2
     1  MAAAAVVVPA EWIKNWEKSG RGEFLHLCRI LSENKSHDSS TYRDFQQALY ELSYHVIKGN
    61  LKHEQASNVL SDISEFREDM PSILADVFCI LDIETNCLEE KSKRDYFTQL VLACLYLVSD
   121  TVLKERLDPE TLESLGLIKQ SQQFNQKSVK IKTKLFYKQQ KFNLLREENE GYAKLIAELG
   181  QDLSGSITSD LILENIKSLI GCFNLDPNRV LDVILEVFEC RPEHDDFFIS LLESYMSMCE
   241  PQTLCHILGF KFKFYQEPNG ETPSSLYRVA AVLLQFNLID LDDLYVHLLP ADNCIMDEHK
   301  REIAEAKQIV RKLTMVVLSS EKMDEREKEK EKEEEKVEKP PDNQKLGLLE ALLKIGDWQH
   361  AQNIMDQMPP YYAASHKLIA LAICKLIHIT IEPLYRRVGV PKGAKGSPVN ALQNKRAPKQ
   421  AESFEDLRRD VFNMFCYLGP HLSHDPILFA KVVRIGKSFM KEFQSDGSKQ EDKEKTEVIL
   481  SCLLSITDQV LLPSLSLMDC NACMSEELWG MFKTFPYQHR YRLYGQWKNE TYNSHPLLVK
   541  VKAQTIDRAK YIMKRLTKEN VKPSGRQIGK LSHSNPTILF DYILSQIQKY DNLITPVVDS
   601  LKYLTSLNYD VLAYCIIEAL ANPEKERMKH DDTTISSWLQ SLASFCGAVF RKYPIDLAGL
   661  LQYVANQLKA GKSFDLLILK EVVQKMAGIE ITEEMTMEQL EAMTGGEQLK AEGGYFGQIR
   721  NTKKSSQRLK DALLDHDLAL PLCLLMAQQR NGVIFQEGGE KHLKLVGKLY DQCHDTLVQF
   781  GGFLASNLST EDYIKRVPSI DVLCNEFHTP HDAAFFLSRP MYAHHISSKY DELKKSEKGS
   841  KQQHKVHKYI TSCEMVMAPV HEAVVSLHVS KVWDDISPQF YATFWSLTMY DLAVPHTSYE
   901  REVNKLKVQM KAIDDNQEMP PNKKKKEKER CTALQDKLLE EEKKQMEHVQ RVLQRLKLEK
   961  DNWLLAKSTK NETITKFLQL CIFPRCIFSA IDAVYCARFV ELVHQQKTPN FSTLLCYDRV
  1021  FSDIIYTVAS CTENEASRYG RFLCCMLETV TRWHSDRATY EKECGNYPGF LTILRATGFD
  1081  GGNKADQLDY ENFRHVVHKW HYKLTKASVH CLETGEYTHI RNILIVLTKI LPWYPKVLNL
  1141  GQALERRVHK ICQEEKEKRP DLYALAMGYS GQLKSRKSYM IPENEFHHKD PPPRNAVASV
  1201  QNGPGGGPSS SSIGSASKSD ESSTEETDKS RERSQCGVKA VNKASSTTPK GNSSNGNSGS
  1261  NSNKAVKEND KEKGKEKEKE KKEKTPATTP EARVLGKDGK EKPKEERPNK DEKARETKER
  1321  TPKSDKEKEK FKKEEKAKDE KFKTTVPNAE SKSTQERERE KEPSRERDIA KEMKSKENVK
  1381  GGEKTPVSGS LKSPVPRSDI PEPEREQKRR KIDTHPSPSH SSTVKDSLIE LKESSAKLYI
  1441  NHTPPPLSKS KEREMDKKDL DKSRERSRER EKKDEKDRKE RKRDHSNNDR EVPPDLTKRR
  1501  KEENGTMGVS KHKSESPCES PYPNEKDKEK NKSKSSGKEK GSDSFKSEKM DKISSGGKKE
  1561  SRHDKEKIEK KEKRDSSGGK EEKKHHKSSD KHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THOC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 42 nTPM
  • epididymis: 36 nTPM
  • thymus: 36 nTPM
  • retina: 32 nTPM
  • ovary: 32 nTPM
  • lymph node: 31 nTPM

Single-cell type

  • alveolar cells type 1: 299 nCPM
  • megakaryocyte-erythroid progenitors: 281 nCPM
  • erythrocyte progenitors: 277 nCPM
  • cone photoreceptor cells: 253 nCPM
  • megakaryocyte progenitors: 243 nCPM
  • sertoli cells: 241 nCPM

Immune cell

  • plasmacytoid DC: 13 nTPM
  • naive CD4 T-cell: 13 nTPM
  • MAIT T-cell: 13 nTPM
  • naive CD8 T-cell: 13 nTPM
  • non-classical monocyte: 12 nTPM
  • memory CD4 T-cell: 12 nTPM

Brain region

  • choroid plexus: 37 nTPM
  • white matter: 30 nTPM
  • cerebellum: 27 nTPM
  • medulla oblongata: 27 nTPM
  • hypothalamus: 26 nTPM
  • basal ganglia: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about THOC2.

Disease | AllUniProt

Conditions THOC2 is implicated in, by any mechanism.

  • Intellectual developmental disorder, X-linked, syndromic, Kumar type (MRXSK) MIM:300957
  • Arthrogryposis multiplex congenita 7, X-linked (AMC7) MIM:301127

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 602 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.08
gnomAD pLI
1
gnomAD missense Z
5.53
DepMap mean gene effect
-2.02
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • THO complex, subunitTHOC2, C-terminal
  • THO complex, subunitTHOC2, N-terminal
  • THO complex subunit 2, N-terminal domain
  • THO complex subunit 2
  • Transcription factor/nuclear export subunit protein 2
  • Transcription- and export-related complex subunit
  • THO complex subunit 2 N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THOC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THOC2 as an antibody target. Whether an autoantibody or antibody against THOC2 could matter depends on whether native THOC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THOC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THOC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THOC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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