Seroatlas · Human Serome Atlas

RIPOR1

Rho family-interacting cell polarization regulator 1

Also known as: FAM65A, FLJ13725, RIPR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZS17
Gene
RIPOR1
Ensembl
ENSG00000039523
Chromosome
16
Canonical length
1223 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables 14-3-3 protein binding activity. Involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Located in several cellular components, including Golgi apparatus; cell leading edge; and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1223 residues, UniProt reviewed canonical sequence.

>Q6ZS17|RIPOR1
     1  MMSLSVRPQR RLLSARVNRS QSFAGVLGSH ERGPSLSFRS FPVFSPPGPP RKPPALSRVS
    61  RMFSVAHPAA KVPQPERLDL VYTALKRGLT AYLEVHQQEQ EKLQGQIRES KRNSRLGFLY
   121  DLDKQVKSIE RFLRRLEFHA SKIDELYEAY CVQRRLRDGA YNMVRAYTTG SPGSREARDS
   181  LAEATRGHRE YTESMCLLES ELEAQLGEFH LRMKGLAGFA RLCVGDQYEI CMKYGRQRWK
   241  LRGRIEGSGK QVWDSEETIF LPLLTEFLSI KVTELKGLAN HVVVGSVSCE TKDLFAALPQ
   301  VVAVDINDLG TIKLSLEVTW SPFDKDDQPS AASSVNKAST VTKRFSTYSQ SPPDTPSLRE
   361  QAFYNMLRRQ EELENGTAWS LSSESSDDSS SPQLSGTARH SPAPRPLVQQ PEPLPIQVAF
   421  RRPETPSSGP LDEEGAVAPV LANGHAPYSR TLSHISEASV DAALAEASVE AVGPESLAWG
   481  PSPPTHPAPT HGEHPSPVPP ALDPGHSATS STLGTTGSVP TSTDPAPSAH LDSVHKSTDS
   541  GPSELPGPTH TTTGSTYSAI TTTHSAPSPL THTTTGSTHK PIISTLTTTG PTLNIIGPVQ
   601  TTTSPTHTMP SPTHTTASPT HTSTSPTHTP TSPTHKTSMS PPTTTSPTPS GMGLVQTATS
   661  PTHPTTSPTH PTTSPILINV SPSTSLELAT LSSPSKHSDP TLPGTDSLPC SPPVSNSYTQ
   721  ADPMAPRTPH PSPAHSSRKP LTSPAPDPSE STVQSLSPTP SPPTPAPQHS DLCLAMAVQT
   781  PVPTAAGGSG DRSLEEALGA LMAALDDYRG QFPELQGLEQ EVTRLESLLM QRQGLTRSRA
   841  SSLSITVEHA LESFSFLNED EDEDNDVPGD RPPSSPEAGA EDSIDSPSAR PLSTGCPALD
   901  AALVRHLYHC SRLLLKLGTF GPLRCQEAWA LERLLREARV LEAVCEFSRR WEIPASSAQE
   961  VVQFSASRPG FLTFWDQCTE RLSCFLCPVE RVLLTFCNQY GARLSLRQPG LAEAVCVKFL
  1021  EDALGQKLPR RPQPGPGEQL TVFQFWSFVE TLDSPTMEAY VTETAEEVLL VRNLNSDDQA
  1081  VVLKALRLAP EGRLRRDGLR ALSSLLVHGN NKVMAAVSTQ LRSLSLGPTF RERALLCFLD
  1141  QLEDEDVQTR VAGCLALGCI KAPEGIEPLV YLCQTDTEAV REAARQSLQQ CGEEGQSAHR
  1201  RLEESLDALP RIFGPGSMAS TAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIPOR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 62 nTPM
  • spleen: 57 nTPM
  • cerebellum: 54 nTPM
  • lung: 52 nTPM
  • heart muscle: 50 nTPM
  • blood vessel: 49 nTPM

Single-cell type

  • podocytes: 772 nCPM
  • cardiomyocytes: 113 nCPM
  • b-cells: 104 nCPM
  • rod photoreceptor cells: 85 nCPM
  • vascular endothelial cells: 77 nCPM
  • pdcs: 73 nCPM

Immune cell

  • memory B-cell: 16 nTPM
  • intermediate monocyte: 16 nTPM
  • non-classical monocyte: 15 nTPM
  • plasmacytoid DC: 14 nTPM
  • classical monocyte: 11 nTPM
  • myeloid DC: 10 nTPM

Brain region

  • cerebral cortex: 125 nTPM
  • hippocampal formation: 120 nTPM
  • basal ganglia: 113 nTPM
  • amygdala: 108 nTPM
  • pons: 105 nTPM
  • cerebellum: 105 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.95
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIPOR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIPOR1 as an antibody target. Whether an autoantibody or antibody against RIPOR1 could matter depends on whether native RIPOR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIPOR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIPOR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIPOR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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