Seroatlas · Human Serome Atlas

GRAP2

GRB2-related adapter protein 2

Also known as: GADS, GRAP2_HUMAN, GRBLG, GrbX, Grf40, Mona

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75791
Gene
GRAP2
Ensembl
ENSG00000100351
Chromosome
22
Canonical length
330 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>O75791|GRAP2
     1  MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF IDIQFPKWFH
    61  EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD NKGNYFLWTE
   121  KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP
   181  SMNRKLSDHP PTLPLQQHQH QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN
   241  DGHCGTGLGS EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV
   301  LDSSNPSWWT GRLHNKLGLF PANYVAPMTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
172 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 172 nTPM
  • lymph node: 15 nTPM
  • tonsil: 12 nTPM
  • bone marrow: 9.7 nTPM
  • spleen: 8.8 nTPM
  • appendix: 7.5 nTPM

Single-cell type

  • platelets: 1,720 nCPM
  • mast cells: 347 nCPM
  • t-cells: 217 nCPM
  • megakaryocytes: 192 nCPM
  • nk-cells: 76 nCPM
  • thymocytes: 41 nCPM

Immune cell

  • total PBMC: 75 nTPM
  • naive CD8 T-cell: 58 nTPM
  • memory CD8 T-cell: 56 nTPM
  • gdT-cell: 52 nTPM
  • MAIT T-cell: 38 nTPM
  • memory CD4 T-cell: 38 nTPM

Brain region

  • white matter: 1.4 nTPM
  • choroid plexus: 1.2 nTPM
  • medulla oblongata: 1.2 nTPM
  • pons: 1 nTPM
  • spinal cord: 1 nTPM
  • thalamus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.12
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRAP2 as an antibody target. Whether an autoantibody or antibody against GRAP2 could matter depends on whether native GRAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GRAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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