Seroatlas · Human Serome Atlas

IST1

IST1 homolog

Also known as: CHMP8, IST1_HUMAN, KIAA0174

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53990
Gene
IST1
Ensembl
ENSG00000182149
Chromosome
16
Canonical length
364 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>P53990|IST1
     1  MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII
    61  REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV
   121  ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD
   181  SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN
   241  TPFSYPLPKG PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
   301  GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL
   361  KKKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
85 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 85 nTPM
  • tonsil: 76 nTPM
  • bone marrow: 76 nTPM
  • tongue: 75 nTPM
  • colon: 64 nTPM
  • kidney: 64 nTPM

Single-cell type

  • neutrophils: 339 nCPM
  • enterocytes: 281 nCPM
  • epicardial cells: 205 nCPM
  • esophageal apical cells: 193 nCPM
  • urothelial cells: 188 nCPM
  • foveolar cells: 183 nCPM

Immune cell

  • neutrophil: 302 nTPM
  • total PBMC: 295 nTPM
  • T-reg: 246 nTPM
  • eosinophil: 245 nTPM
  • basophil: 235 nTPM
  • classical monocyte: 196 nTPM

Brain region

  • white matter: 73 nTPM
  • basal ganglia: 67 nTPM
  • midbrain: 64 nTPM
  • medulla oblongata: 63 nTPM
  • cerebellum: 61 nTPM
  • thalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
gnomAD missense Z
-0.66
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Vacuolar protein sorting-associated protein Ist1
  • Vacuolar protein sorting-associated protein IST1-like
  • Regulator of Vps4 activity in the MVB pathway

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IST1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IST1 as an antibody target. Whether an autoantibody or antibody against IST1 could matter depends on whether native IST1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IST1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IST1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IST1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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