Seroatlas · Human Serome Atlas

CHMP1A

Charged multivesicular body protein 1a

Also known as: CHM1A_HUMAN, CHMP1, KIAA0047, PCOLN3, PRSM1, Vps46A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HD42
Gene
CHMP1A
Ensembl
ENSG00000131165
Chromosome
16
Canonical length
196 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q9HD42|CHMP1A
     1  MDDTLFQLKF TAKQLEKLAK KAEKDSKAEQ AKVKKALLQK NVECARVYAE NAIRKKNEGV
    61  NWLRMASRVD AVASKVQTAV TMKGVTKNMA QVTKALDKAL STMDLQKVSS VMDRFEQQVQ
   121  NLDVHTSVME DSMSSATTLT TPQEQVDSLI MQIAEENGLE VLDQLSQLPE GASAVGESSV
   181  RSQEDQLSRR LAALRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHMP1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 72 nTPM
  • cerebral cortex: 56 nTPM
  • hippocampal formation: 54 nTPM
  • amygdala: 54 nTPM
  • skin: 53 nTPM
  • skeletal muscle: 51 nTPM

Single-cell type

  • esophageal apical cells: 271 nCPM
  • late spermatids: 208 nCPM
  • esophageal suprabasal cells: 146 nCPM
  • colonocytes: 115 nCPM
  • enterocytes: 107 nCPM
  • extravillous trophoblasts: 93 nCPM

Immune cell

  • eosinophil: 109 nTPM
  • neutrophil: 86 nTPM
  • non-classical monocyte: 83 nTPM
  • basophil: 67 nTPM
  • total PBMC: 64 nTPM
  • intermediate monocyte: 63 nTPM

Brain region

  • hippocampal formation: 35 nTPM
  • amygdala: 35 nTPM
  • thalamus: 34 nTPM
  • cerebral cortex: 34 nTPM
  • medulla oblongata: 32 nTPM
  • hypothalamus: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHMP1A.

Disease | AllUniProt

Conditions CHMP1A is implicated in, by any mechanism.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 270 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHMP1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHMP1A as an antibody target. Whether an autoantibody or antibody against CHMP1A could matter depends on whether native CHMP1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHMP1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHMP1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHMP1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...