MYOG
Myogenin
Also known as: bHLHc3, MYF4, MYOG_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P15173
- Gene
- MYOG
- Ensembl
- ENSG00000122180
- Chromosome
- 1
- Canonical length
- 224 aa
- Protein class
- Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
224 residues, UniProt reviewed canonical sequence.
>P15173|MYOG
1 MELYETSPYF YQEPRFYDGE NYLPVHLQGF EPPGYERTEL TLSPEAPGPL EDKGLGTPEH
61 CPGQCLPWAC KVCKRKSVSV DRRRAATLRE KRRLKKVNEA FEALKRSTLL NPNQRLPKVE
121 ILRSAIQYIE RLQALLSSLN QEERDLRYRG GGGPQPGVPS ECSSHSASCS PEWGSALEFS
181 ANPGDHLLTA DPTDAHNLHS LTSIVDSITV EDVSVAFPDE TMPNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MYOG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 98 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 98 nTPM
- tongue: 44 nTPM
- salivary gland: 4.9 nTPM
- prostate: 2.1 nTPM
- esophagus: 1.7 nTPM
- thymus: 1.5 nTPM
Single-cell type
- thymic myoid cells: 53 nCPM
- myonuclei: 32 nCPM
- adipocytes: 0.8 nCPM
- myosatellite cells: 0.8 nCPM
- podocytes: 0.3 nCPM
- fibro-adipogenic progenitors: 0.2 nCPM
Immune cell
- basophil: 0.5 nTPM
- neutrophil: 0.2 nTPM
- NK-cell: 0.2 nTPM
- non-classical monocyte: 0.2 nTPM
- eosinophil: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
Brain region
- cerebellum: 6.4 nTPM
- amygdala: 2 nTPM
- hippocampal formation: 1.9 nTPM
- cerebral cortex: 1.8 nTPM
- pons: 1.8 nTPM
- basal ganglia: 1.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.41
- gnomAD pLI
- 0.9
- gnomAD missense Z
- 0.55
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to estradiol stimulus
- cellular response to growth factor stimulus
- cellular response to lithium ion
- cellular response to tumor necrosis factor
- muscle cell fate commitment
- negative regulation of cell population proliferation
- ossification
- positive regulation of muscle atrophy
- positive regulation of myoblast differentiation
- positive regulation of myotube differentiation
- positive regulation of skeletal muscle fiber development
- positive regulation of transcription by RNA polymerase II
- regulation of cell cycle
- regulation of myoblast fusion
- regulation of skeletal muscle satellite cell proliferation
- response to denervation involved in regulation of muscle adaptation
- response to electrical stimulus involved in regulation of muscle adaptation
- response to muscle activity involved in regulation of muscle adaptation
- skeletal muscle cell differentiation
- skeletal muscle fiber development
- skeletal muscle tissue development
- striated muscle atrophy
Molecular functions
- chromatin DNA binding
- DNA-binding transcription activator activity
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- E-box binding
- protein dimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MYOG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MYOG as an antibody target. Whether an autoantibody or antibody against MYOG could matter depends on whether native MYOG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MYOG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MYOG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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