Seroatlas · Human Serome Atlas

MRTFB

Myocardin-related transcription factor B

Also known as: FLJ31823, MKL2, MRTF-B, MRTFB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULH7
Gene
MRTFB
Ensembl
ENSG00000186260
Chromosome
16
Canonical length
1088 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in positive regulation of miRNA transcription; positive regulation of striated muscle tissue development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; postsynapse; and presynapse. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1088 residues, UniProt reviewed canonical sequence.

>Q9ULH7|MRTFB
     1  MIDSSKKQQQ GFPEILTAGD FEPLKEKECL EGSNQKSLKE VLQLRLQQRR TREQLVDQGI
    61  MPPLKSPAAF HEQIKSLERA RTENFLKHKI RSRPDRSELV RMHILEETFA EPSLQATQMK
   121  LKRARLADDL NEKIAQRPGP MELVEKNILP VDSSVKEAII GVGKEDYPHT QGDFSFDEDS
   181  SDALSPDQPA SQESQGSAAS PSEPKVSESP SPVTTNTPAQ FASVSPTVPE FLKTPPTADQ
   241  PPPRPAAPVL PTNTVSSAKP GPALVKQSHP KNPNDKHRSK KCKDPKPRVK KLKYHQYIPP
   301  DQKGEKNEPQ MDSNYARLLQ QQQLFLQLQI LSQQKQHYNY QTILPAPFKP LNDKNSNSGN
   361  SALNNATPNT PRQNTSTPVR KPGPLPSSLD DLKVSELKTE LKLRGLPVSG TKPDLIERLK
   421  PYQEVNSSGL AAGGIVAVSS SAIVTSNPEV TVALPVTTLH NTVTSSVSTL KAELPPTGTS
   481  NATRVENVHS PLPISPSPSE QSSLSTDDTN MADTFTEIMT MMSPSQFLSS SPLRMTNNED
   541  SLSPTSSTLS NLELDAAEKD RKLQEKEKQI EELKRKLEQE QKLVEVLKMQ LEVEKRGQQQ
   601  RPLEAQPSAP GHSVKSDQKH GSLGSSIKDE ASLPDCSSSR QPIPVASHAV GQPVSTGGQT
   661  LVAKKAVVIK QEVPVGQAEQ QSVVSQFYVS SQGQPPPAVV AQPQALLTTQ TAQLLLPVSI
   721  QGSSVTSVQL PVGSLKLQTS PQAGMQTQPQ IATAAQIPTA ALASGLAPTV PQTQDTFPQH
   781  VLSQPQQVRK VFTNSASSNT VLPYQRHPAP AVQQPFINKA SNSVLQSRNA PLPSLQNGPN
   841  TPNKPSSPPP PQQFVVQHSL FGSPVAKTKD PPRYEEAIKQ TRSTQAPLPE ISNAHSQQMD
   901  DLFDILIKSG EISLPIKEEP SPISKMRPVT ASITTMPVNT VVSRPPPQVQ MAPPVSLEPM
   961  GSLSASLENQ LEAFLDGTLP SANEIPPLQS SSEDREPFSL IEDLQNDLLS HSGMLDHSHS
  1021  PMETSETQFA AGTPCLSLDL SDSNLDNMEW LDITMPNSSS GLTPLSTTAP SMFSADFLDP
  1081  QDLPLPWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRTFB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 28 nTPM
  • parathyroid gland: 21 nTPM
  • placenta: 20 nTPM
  • adipose tissue: 20 nTPM
  • cervix: 18 nTPM
  • breast: 17 nTPM

Single-cell type

  • vascular endothelial cells: 602 nCPM
  • respiratory basal cells: 600 nCPM
  • respiratory secretory cells: 493 nCPM
  • pituitary stem cells: 483 nCPM
  • brain excitatory neurons: 399 nCPM
  • brain inhibitory neurons: 369 nCPM

Immune cell

  • memory B-cell: 3.7 nTPM
  • naive CD4 T-cell: 2.4 nTPM
  • memory CD4 T-cell: 1.9 nTPM
  • MAIT T-cell: 1.7 nTPM
  • plasmacytoid DC: 1.7 nTPM
  • naive B-cell: 1.5 nTPM

Brain region

  • cerebral cortex: 168 nTPM
  • basal ganglia: 152 nTPM
  • hippocampal formation: 145 nTPM
  • amygdala: 131 nTPM
  • hypothalamus: 114 nTPM
  • white matter: 104 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRTFB.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • MRTFB-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRTFB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRTFB as an antibody target. Whether an autoantibody or antibody against MRTFB could matter depends on whether native MRTFB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRTFB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRTFB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRTFB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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