Seroatlas · Human Serome Atlas

OLFM2

Noelin-2

Also known as: NOE2, NOE2_HUMAN, OlfC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95897
Gene
OLFM2
Ensembl
ENSG00000105088
Chromosome
19
Canonical length
454 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Involved in positive regulation of smooth muscle cell differentiation. Acts upstream of or within protein secretion. Located in cytoplasm; extracellular region; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>O95897|OLFM2
     1  MWPLTVPPPL LLLLCSGLAG QTLFQNPEEG WQLYTSAQAP DGKCICTAVI PAQSTCSRDG
    61  RSRELRQLME KVQNVSQSME VLELRTYRDL QYVRGMETLM RSLDARLRAA DGSLSAKSFQ
   121  ELKDRMTELL PLSSVLEQYK ADTRTIVRLR EEVRNLSGSL AAIQEEMGAY GYEDLQQRVM
   181  ALEARLHACA QKLGCGKLTG VSNPITVRAM GSRFGSWMTD TMAPSADSRV WYMDGYYKGR
   241  RVLEFRTLGD FIKGQNFIQH LLPQPWAGTG HVVYNGSLFY NKYQSNVVVK YHFRSRSVLV
   301  QRSLPGAGYN NTFPYSWGGF SDMDFMVDES GLWAVYTTNQ NAGNIVVSRL DPHTLEVMRS
   361  WDTGYPKRSA GEAFMICGVL YVTNSHLAGA KVYFAYFTNT SSYEYTDVPF HNQYSHISML
   421  DYNPRERALY TWNNGHQVLY NVTLFHVIST SGDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLFM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
168 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 168 nTPM
  • cerebral cortex: 166 nTPM
  • amygdala: 158 nTPM
  • hippocampal formation: 113 nTPM
  • skin: 85 nTPM
  • hypothalamus: 84 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 225 nCPM
  • astrocytes: 200 nCPM
  • basal keratinocytes: 140 nCPM
  • bergmann glia: 137 nCPM
  • müller glia: 126 nCPM
  • suprabasal keratinocytes: 122 nCPM

Immune cell

  • eosinophil: 50 nTPM
  • basophil: 21 nTPM
  • T-reg: 17 nTPM
  • naive CD4 T-cell: 14 nTPM
  • naive CD8 T-cell: 9 nTPM
  • memory CD4 T-cell: 7 nTPM

Brain region

  • midbrain: 166 nTPM
  • cerebral cortex: 154 nTPM
  • medulla oblongata: 149 nTPM
  • pons: 149 nTPM
  • basal ganglia: 118 nTPM
  • amygdala: 109 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.08
gnomAD missense Z
2.34
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OLFM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLFM2 as an antibody target. Whether an autoantibody or antibody against OLFM2 could matter depends on whether native OLFM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLFM2 is annotated as secreted, so native OLFM2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OLFM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OLFM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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