Seroatlas · Human Serome Atlas

SRFBP1

Serum response factor-binding protein 1

Also known as: BUD22, FLJ25286, p49, Rlb1, SRFB1_HUMAN, STRAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEF9
Gene: SRFBP1
Ensembl: ENSG00000151304
Chromosome: 5
Canonical length: 429 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli rim

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of 90S preribosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q8NEF9|SRFBP1
     1  MAQPGTLNLN NEVVKMRKEV KRIRVLVIRK LVRSVGRLKS KKGTEDALLK NQRRAQRLLE
    61  EIHAMKELKP DIVTKSALGD DINFEKIFKK PDSTATERAI ARLAVHPLLK KKIDVLKAAV
   121  QAFKEARQNV AEVESSKNAS EDNHSENTLY SNDNGSNLQR EATVISEQKV KETKILAKKP
   181  IHNSKEKIAK MEHGPKAVTI ANSPSKPSEK DSVVSLESQK TPADPKLKTL SQTKKNKGSD
   241  SSLSGNSDGG EEFCEEEKEY FDDSTEERFY KQSSMSEDSD SGDDFFIGKV RRTRKKESSC
   301  HSSVKEQKPL EKVFLKEDTG ETHGDTRNDK IKPSTETRKL ESVFFHSLSG SKSSRRNFKE
   361  QAPKTRSLDF PQNEPQIKNQ FNKKLSGRLE NTKQQLQLPL HPSWEASRRR KEQQSNIAVF
   421  QGKKITFDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRFBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 8.5 nTPM

Expression across tissuesHPA

Tissue

breast: 8.5 nTPM
thyroid gland: 7.7 nTPM
urinary bladder: 7.2 nTPM
lymph node: 6.9 nTPM
parathyroid gland: 6.9 nTPM
kidney: 6.7 nTPM

Single-cell type

epicardial cells: 130 nCPM
fallopian secretory cells: 91 nCPM
erythrocyte progenitors: 87 nCPM
ocular epithelial cells: 80 nCPM
megakaryocyte progenitors: 75 nCPM
microglia: 72 nCPM

Immune cell

intermediate monocyte: 13 nTPM
naive CD8 T-cell: 11 nTPM
non-classical monocyte: 10 nTPM
memory B-cell: 10 nTPM
myeloid DC: 9.6 nTPM
plasmacytoid DC: 9 nTPM

Brain region

white matter: 15 nTPM
cerebellum: 15 nTPM
midbrain: 14 nTPM
thalamus: 14 nTPM
medulla oblongata: 13 nTPM
spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: -1.62
DepMap mean gene effect: -0.86
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maturation of SSU-rRNA

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Bud22 domain
Bud22/Serum response factor-binding protein 1
BUD22

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRFBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRFBP1 as an antibody target. Whether an autoantibody or antibody against SRFBP1 could matter depends on whether native SRFBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRFBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRFBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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