Seroatlas · Human Serome Atlas

SNX15

Sorting nexin-15

Also known as: SNX15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRS6
Gene
SNX15
Ensembl
ENSG00000110025
Chromosome
11
Canonical length
342 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Vesicles,Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q9NRS6|SNX15
     1  MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK RYSDFRKLHG
    61  DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVHI PALNNSPQLK
   121  EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP PDDPRLSQLL PAERRGLEEL EVPVDPPPSS
   181  PAQEALDLLF NCESTEEASG SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE
   241  SARLDQEPWE PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH
   301  VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 28 nTPM
  • skeletal muscle: 25 nTPM
  • colon: 22 nTPM
  • blood vessel: 22 nTPM
  • spinal cord: 21 nTPM
  • cerebral cortex: 20 nTPM

Single-cell type

  • bergmann glia: 18 nCPM
  • oligodendrocytes: 13 nCPM
  • other brain neurons: 11 nCPM
  • brain excitatory neurons: 11 nCPM
  • brain inhibitory neurons: 9.3 nCPM
  • oligodendrocyte progenitor cells: 9 nCPM

Immune cell

  • non-classical monocyte: 24 nTPM
  • intermediate monocyte: 16 nTPM
  • classical monocyte: 14 nTPM
  • eosinophil: 14 nTPM
  • myeloid DC: 9.4 nTPM
  • basophil: 9.2 nTPM

Brain region

  • medulla oblongata: 30 nTPM
  • cerebellum: 30 nTPM
  • cerebral cortex: 29 nTPM
  • basal ganglia: 27 nTPM
  • midbrain: 27 nTPM
  • white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.87
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX15 as an antibody target. Whether an autoantibody or antibody against SNX15 could matter depends on whether native SNX15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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