Seroatlas · Human Serome Atlas

EQTN

Equatorin

Also known as: AFAF, C9orf11, EQTN_HUMAN, equatorin, SPACA8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQ60
Gene
EQTN
Ensembl
ENSG00000120160
Chromosome
9
Canonical length
294 aa
Protein class
Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Plasma membrane,Actin filaments
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be involved in acrosomal vesicle exocytosis; endocytosis; and fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in early endosome and nucleus. Predicted to be active in inner acrosomal membrane; outer acrosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>Q9NQ60|EQTN
     1  MNFILFIFIP GVFSLKSSTL KPTIEALPNV LPLNEDVNKQ EEKNEDHTPN YAPANEKNGN
    61  YYKDIKQYVF TTQNPNGTES EISVRATTDL NFALKNDKTV NATTYEKSTI EEETTTSEPS
   121  HKNIQRSTPN VPAFWTMLAK AINGTAVVMD DKDQLFHPIP ESDVNATQGE NQPDLEDLKI
   181  KIMLGISLMT LLLFVVLLAF CSATLYKLRH LSYKSCESQY SVNPELATMS YFHPSEGVSD
   241  TSFSKSAESS TFLGTTSSDM RRSGTRTSES KIMTDIISIG SDNEMHENDE SVTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EQTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • testis: 35 nTPM
  • spinal cord: 0.6 nTPM
  • choroid plexus: 0.5 nTPM
  • ovary: 0.5 nTPM
  • duodenum: 0.4 nTPM
  • epididymis: 0.4 nTPM

Single-cell type

  • early spermatids: 758 nCPM
  • late primary spermatocytes: 554 nCPM
  • late spermatids: 36 nCPM
  • retinal ganglion cells: 3.9 nCPM
  • oligodendrocytes: 3.4 nCPM
  • sertoli cells: 3.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 6.2 nTPM
  • medulla oblongata: 5 nTPM
  • thalamus: 4.8 nTPM
  • basal ganglia: 4.1 nTPM
  • pons: 4 nTPM
  • midbrain: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
gnomAD missense Z
-0.35
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Equatorin
  • Acrosome formation-associated factor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EQTN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EQTN as an antibody target. Whether an autoantibody or antibody against EQTN could matter depends on whether native EQTN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EQTN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EQTN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EQTN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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