SNF2, N-terminal domain
IPR000330
Definition
This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54) and chromatin unwinding (e.g., ISWI), as well as several other proteins with limited functional information (e.g., lodestar, ETL1) [[cite:PMID:7651832], [cite:PMID:14729263], [cite:PMID:21549307]]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in increased accessibility of DNA to transcription factors PMID:16935875. Proteins containing this domain appear to be distantly related to the DEAD/DEAH box helicases.
32 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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