Seroatlas · Human Serome Atlas

HMGXB4

HMG domain-containing protein 4

Also known as: HMG2L1, HMGX4_HUMAN, P53N, THC211630

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGU5
Gene: HMGXB4
Ensembl: ENSG00000100281
Chromosome: 22
Canonical length: 601 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

601 residues, UniProt reviewed canonical sequence.

>Q9UGU5|HMGXB4
     1  MAYDDSVKKE DCFDGDHTFE DIGLAAGRSQ REKKRSYKDF LREEEEIAAQ VRNSSKKKLK
    61  DSELYFLGTD THKKKRKHSS DDYYYGDISS LESSQKKKKK SSPQSTDTAM DLLKAITSPL
   121  AAGSKPSKKT GEKSSGSSSH SESKKEHHRK KVSGSSGELP LEDGGSHKSK KMKPLYVNTE
   181  TLTLREPDGL KMKLILSPKE KGSSSVDEES FQYPSQQATV KKSSKKSARD EQGALLLGHE
   241  LQSFLKTARK KHKSSSDAHS SPGPEGCGSD ASQFAESHSA NLDLSGLEPI LVESDSSSGG
   301  ELEAGELVID DSYREIKKKK KSKKSKKKKD KEKHKEKRHS KSKRSLGLSA VPVGEVTVTS
   361  GPPPSIPYAG AAAPPLPLPG LHTDGHSEKK KKKEEKDKER ERGEKPKKKN MSAYQVFCKE
   421  YRVTIVADHP GIDFGELSKK LAEVWKQLPE KDKLIWKQKA QYLQHKQNKA EATTVKRKAS
   481  SSEGSMKVKA SSVGVLSPQK KSPPTTMLLP ASPAKAPETE PIDVAAHLQL LGESLSLIGH
   541  RLQETEGMVA VSGSLSVLLD SIICALGPLA CLTTQLPELN GCPKQVLSNT LDNIAYIMPG
   601  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMGXB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 22 nTPM
ovary: 13 nTPM
endometrium: 11 nTPM
thymus: 11 nTPM
smooth muscle: 8.8 nTPM
placenta: 8.4 nTPM

Single-cell type

sertoli cells: 148 nCPM
esophageal apical cells: 112 nCPM
early primary spermatocytes: 100 nCPM
granulosa cells: 88 nCPM
syncytiotrophoblasts: 87 nCPM
extravillous trophoblasts: 85 nCPM

Immune cell

basophil: 34 nTPM
neutrophil: 19 nTPM
eosinophil: 17 nTPM
intermediate monocyte: 15 nTPM
memory CD8 T-cell: 14 nTPM
non-classical monocyte: 14 nTPM

Brain region

white matter: 17 nTPM
cerebellum: 15 nTPM
basal ganglia: 14 nTPM
cerebral cortex: 14 nTPM
thalamus: 14 nTPM
medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.49
gnomAD missense Z: 1.24
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

NURF complex

Protein domainsUniProt · Pfam · InterPro

High mobility group box domain
High mobility group box domain superfamily
HMG (high mobility group) box
Domain of unknown function DUF4171
HMG domain-containing protein 4
HMG domain-containing protein 4, HMG-box
Domain of unknown function (DUF4171)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMGXB4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMGXB4 as an antibody target. Whether an autoantibody or antibody against HMGXB4 could matter depends on whether native HMGXB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMGXB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMGXB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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