SNF2/RAD5-like, C-terminal helicase domain

Definition

This entry represents the C-terminal helicase domain of yeast DNA repair and recombination protein RAD54 [[cite:PMID:32502392], [cite:PMID:31492866]] and similar sequences from all domains in life. The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA [[cite:PMID:15627498], [cite:PMID:18508648], [cite:PMID:19234488], [cite:PMID:18786849], [cite:PMID:16935875], [cite:PMID:16568948]].

32 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (32 proteins: gene, accession, name)

• ATRX
• BTAF1
• CHD1
• CHD1L
• CHD2
• CHD3
• CHD4
• CHD5
• CHD6
• CHD7
• CHD8
• CHD9
• EP400
• ERCC6
• ERCC6L
• ERCC6L2
• HELLS
• HLTF
• INO80
• RAD54B
• RAD54L
• RAD54L2
• SHPRH
• SMARCA1
• SMARCA2
• SMARCA4
• SMARCA5
• SMARCAD1
• SMARCAL1
• SRCAP
• TTF2
• ZRANB3