Seroatlas · Human Serome Atlas

BEX4

Protein BEX4

Also known as: BEX4_HUMAN, BEXL1, FLJ10097

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWD9
Gene: BEX4
Ensembl: ENSG00000102409
Chromosome: X
Canonical length: 120 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>Q9NWD9|BEX4
     1  MESKEELAAN NLNGENAQQE NEGGEQAPTQ NEEESRHLGG GEGQKPGGNI RRGRVRRLVP
    61  NFRWAIPNRH IEHNEARDDV ERFVGQMMEI KRKTREQQMR HYMRFQTPEP DNHYDFCLIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 284 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 284 nTPM
cerebral cortex: 256 nTPM
basal ganglia: 255 nTPM
epididymis: 251 nTPM
amygdala: 228 nTPM
hippocampal formation: 220 nTPM

Single-cell type

epididymal principal cells: 618 nCPM
esophageal apical cells: 611 nCPM
syncytiotrophoblasts: 440 nCPM
megakaryocytes: 427 nCPM
cytotrophoblasts: 355 nCPM
epididymal basal cells: 349 nCPM

Immune cell

basophil: 119 nTPM
NK-cell: 101 nTPM
plasmacytoid DC: 79 nTPM
naive CD4 T-cell: 66 nTPM
naive CD8 T-cell: 52 nTPM
myeloid DC: 51 nTPM

Brain region

hypothalamus: 175 nTPM
cerebral cortex: 163 nTPM
midbrain: 127 nTPM
basal ganglia: 126 nTPM
white matter: 126 nTPM
pons: 124 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.67
gnomAD missense Z: 0.24
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BEX4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SIRT2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEX4 as an antibody target. Whether an autoantibody or antibody against BEX4 could matter depends on whether native BEX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...