HOXA10

Protein identityUniProt · HPA

UniProt accession

P31260

Gene

HOXA10

Ensembl

ENSG00000253293

Chromosome

7

Canonical length

410 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>P31260|HOXA10
     1  MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGGGGGGAG GGGGGGYYAH
    61  GGVYLPPAAD LPYGLQSCGL FPTLGGKRNE AASPGSGGGG GGLGPGAHGY GPSPIDLWLD
   121  APRSCRMEPP DGPPPPPQQQ PPPPPQPPQP APQATSCSFA QNIKEESSYC LYDSADKCPK
   181  VSATAAELAP FPRGPPPDGC ALGTSSGVPV PGYFRLSQAY GTAKGYGSGG GGAQQLGAGP
   241  FPAQPPGRGF DLPPALASGS ADAARKERAL DSPPPPTLAC GSGGGSQGDE EAHASSSAAE
   301  ELSPAPSESS KASPEKDSLG NSKGENAANW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY
   361  LTRERRLEIS RSVHLTDRQV KIWFQNRRMK LKKMNRENRI RELTANFNFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.69

Highest tissue expression

67 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.88

gnomAD missense Z

-1.07

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterior/posterior pattern specification
• embryonic limb morphogenesis
• male gonad development
• positive regulation of transcription by RNA polymerase II
• prostate gland development
• proximal/distal pattern formation
• regulation of transcription by RNA polymerase II
• response to estrogen
• response to testosterone
• single fertilization
• skeletal system development
• spermatogenesis
• uterus development

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• histone deacetylase binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytoplasm
• nucleoplasm
• nucleus
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain, metazoa
• Homeobox protein Hox-A10/abdominal-B-like
• Homeodomain

KeywordsUniProt

• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of HOXA10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SIRT2