Sirtuin, catalytic core small domain superfamily

Definition

The catalytic core of sirtuin proteins consists of a large and a small domains. The large domain has a Rossmann fold and binds NAD+. The small domain is composed of residues from two insertions in the Rossmann fold that form a helical and a zinc binding modules [[cite:PMID:11336676], [cite:PMID:12408821]]. This superfamily represents the catalytic core small domain.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• SIRT1
• SIRT2
• SIRT3
• SIRT4
• SIRT5