SARS1

Protein identityUniProt · HPA

UniProt accession

P49591

Gene

SARS1

Ensembl

ENSG00000031698

Chromosome

1

Canonical length

514 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>P49591|SARS1
     1  MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA DNLNKLKNLC
    61  SKTIGEKMKK KEPVGDDESV PENVLSFDDL TADALANLKV SQIKKVRLLI DEAILKCDAE
   121  RIKLEAERFE NLREIGNLLH PSVPISNDED VDNKVERIWG DCTVRKKYSH VDLVVMVDGF
   181  EGEKGAVVAG SRGYFLKGVL VFLEQALIQY ALRTLGSRGY IPIYTPFFMR KEVMQEVAQL
   241  SQFDEELYKV IGKGSEKSDD NSYDEKYLIA TSEQPIAALH RDEWLRPEDL PIKYAGLSTC
   301  FRQEVGSHGR DTRGIFRVHQ FEKIEQFVYS SPHDNKSWEM FEEMITTAEE FYQSLGIPYH
   361  IVNIVSGSLN HAASKKLDLE AWFPGSGAFR ELVSCSNCTD YQARRLRIRY GQTKKMMDKV
   421  EFVHMLNATM CATTRTICAI LENYQTEKGI TVPEKLKEFM PPGLQELIPF VKPAPIEQEP
   481  SKKQKKQHEG SKKKAAARDV TLENRLQNME VTDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SARS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

141 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SARS1.

Disease | AllUniProt

Conditions SARS1 is implicated in, by any mechanism.

• Neurodevelopmental disorder with microcephaly, ataxia, and seizures (NEDMAS) MIM:617709

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Neurodevelopmental disorder with microcephaly, ataxia, and seizures
• Cerebral arteriovenous malformation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.21

gnomAD pLI

1

DepMap mean gene effect

-2.58

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoplasmic translation
• negative regulation of angiogenesis
• negative regulation of transcription by RNA polymerase II
• selenocysteine incorporation
• seryl-tRNA aminoacylation
• translation
• tRNA modification
• negative regulation of vascular endothelial growth factor production

Molecular functions

• ATP binding
• enzyme binding
• molecular adaptor activity
• protein homodimerization activity
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• serine-tRNA ligase activity
• tRNA binding
• selenocysteine-tRNA ligase activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
• Serine-tRNA ligase, type1
• Aminoacyl-tRNA synthetase, class II
• Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
• Serine-tRNA ligase catalytic core domain
• Serine-tRNA synthetase, type1, N-terminal domain superfamily
• Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
• tRNA synthetase class II core domain (G, H, P, S and T)
• Serine-tRNA synthetase, type1, N-terminal
• Seryl-tRNA synthetase N-terminal domain

KeywordsUniProt

• Acetylation
• Aminoacyl-tRNA synthetase
• ATP-binding
• Cytoplasm
• DNA-binding
• Epilepsy
• Intellectual disability
• Ligase
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Protein biosynthesis
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of SARS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• METTL6
• SIRT2
• DUS3L