Seroatlas · Human Serome Atlas

DNAJC5B

DnaJ homolog subfamily C member 5B

Also known as: CSP-beta, DNJ5B_HUMAN, MGC26226

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UF47
Gene: DNAJC5B
Ensembl: ENSG00000147570
Chromosome: 8
Canonical length: 199 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins that is characterized by an N-terminal DNAJ domain, a linker region, and a cysteine-rich C-terminal domain. The encoded protein, together with heat shock protein 70, is thought to regulate the proper folding of other proteins. The orthologous mouse protein is membrane-associated and is targeted to the trans-golgi network. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q9UF47|DNAJC5B
     1  MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK NPDDPAATEK
    61  FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KALFVIVGLL
   121  TGCYFCCCLC CCCNCCCGHC RPESSVPEED FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN
   181  ANEKTQLIKE GSRSYCTDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

testis: 58 nTPM
lymph node: 7.2 nTPM
lung: 5.7 nTPM
tonsil: 3.5 nTPM
tongue: 3 nTPM
appendix: 2.8 nTPM

Single-cell type

late spermatids: 4,363 nCPM
early spermatids: 1,215 nCPM
late primary spermatocytes: 386 nCPM
kupffer cells: 31 nCPM
sertoli cells: 11 nCPM
macrophages: 10 nCPM

Immune cell

memory B-cell: 5.8 nTPM
naive B-cell: 1.9 nTPM
myeloid DC: 1.2 nTPM
classical monocyte: 0.6 nTPM
plasmacytoid DC: 0.6 nTPM
intermediate monocyte: 0.5 nTPM

Brain region

white matter: 1.2 nTPM
medulla oblongata: 0.6 nTPM
thalamus: 0.5 nTPM
cerebral cortex: 0.2 nTPM
pons: 0.2 nTPM
spinal cord: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SGTA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC5B as an antibody target. Whether an autoantibody or antibody against DNAJC5B could matter depends on whether native DNAJC5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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