Seroatlas · Human Serome Atlas

CD99L2

CD99 antigen-like protein 2

Also known as: C99L2_HUMAN, CD99B, MIC2L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCZ2
Gene: CD99L2
Ensembl: ENSG00000102181
Chromosome: X
Canonical length: 262 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q8TCZ2|CD99L2
     1  MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT TTTTNRPGTT
    61  RAPAKPPGSG LDLADALDDQ DDGRRKPGIG GRERWNHVTT TTKRPVTTRA PANTLGNDFD
   121  LADALDDRND RDDGRRKPIA GGGGFSDKDL EDIVGGGEYK PDKGKGDGRY GSNDDPGSGM
   181  VAEPGTIAGV ASALAMALIG AVSSYISYQQ KKFCFSIQQG LNADYVKGEN LEAVVCEEPQ
   241  VKYSTLHTQS AEPPPPPEPA RI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD99L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 170 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 170 nTPM
cerebral cortex: 109 nTPM
tongue: 93 nTPM
spinal cord: 86 nTPM
hypothalamus: 77 nTPM
midbrain: 75 nTPM

Single-cell type

myonuclei: 145 nCPM
thymic myoid cells: 126 nCPM
respiratory ionocytes: 107 nCPM
retinal ganglion cells: 89 nCPM
oligodendrocytes: 82 nCPM
other brain neurons: 77 nCPM

Immune cell

non-classical monocyte: 13 nTPM
classical monocyte: 8.6 nTPM
myeloid DC: 8.1 nTPM
intermediate monocyte: 7.6 nTPM
basophil: 7.4 nTPM
NK-cell: 7.2 nTPM

Brain region

pons: 235 nTPM
cerebral cortex: 216 nTPM
medulla oblongata: 204 nTPM
thalamus: 203 nTPM
hypothalamus: 182 nTPM
midbrain: 177 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD99L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SGTA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD99L2 as an antibody target. Whether an autoantibody or antibody against CD99L2 could matter depends on whether native CD99L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD99L2 is annotated at the cell surface, where native CD99L2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD99L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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