Seroatlas · Human Serome Atlas

RRP1

Ribosomal RNA processing protein 1 homolog A

Also known as: D21S2056E, NNP-1, Nop52, RRP1_HUMAN, RRP1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56182
Gene: RRP1
Ensembl: ENSG00000160214
Chromosome: 21
Canonical length: 461 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitotic chromosome

OverviewNCBI Gene

The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>P56182|RRP1
     1  MVSRVQLPPE IQLAQRLAGN EQVTRDRAVR KLRKYIVART QRAAGGFTHD ELLKVWKGLF
    61  YCMWMQDKPL LQEELGRTIS QLVHAFQTTE AQHLFLQAFW QTMNREWTGI DRLRLDKFYM
   121  LMRMVLNESL KVLKMQGWEE RQIEELLELL MTEILHPSSQ APNGVKSHFI EIFLEELTKV
   181  GAEELTADQN LKFIDPFCRI AARTKDSLVL NNITRGIFET IVEQAPLAIE DLLNELDTQD
   241  EEVASDSDES SEGGERGDAL SQKRSEKPPA GSICRAEPEA GEEQAGDDRD SGGPVLQFDY
   301  EAVANRLFEM ASRQSTPSQN RKRLYKVIRK LQDLAGGIFP EDEIPEKACR RLLEGRRQKK
   361  TKKQKRLLRL QQERGKGEKE PPSPGMERKR SRRRGVGADP EARAEAGEQP GTAERALLRD
   421  QPRGRGQRGA RQRRRTPRPL TSARAKAANV QEPEKKKKRR E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

esophagus: 16 nTPM
liver: 13 nTPM
skeletal muscle: 12 nTPM
skin: 11 nTPM
cerebral cortex: 10 nTPM
hippocampal formation: 10 nTPM

Single-cell type

esophageal basal cells: 87 nCPM
esophageal suprabasal cells: 81 nCPM
suprabasal keratinocytes: 67 nCPM
oocytes: 65 nCPM
basal keratinocytes: 61 nCPM
migrating cytotrophoblasts: 47 nCPM

Immune cell

MAIT T-cell: 14 nTPM
NK-cell: 13 nTPM
naive B-cell: 13 nTPM
naive CD4 T-cell: 12 nTPM
memory CD8 T-cell: 11 nTPM
memory B-cell: 11 nTPM

Brain region

white matter: 20 nTPM
cerebral cortex: 18 nTPM
hippocampal formation: 17 nTPM
medulla oblongata: 16 nTPM
basal ganglia: 15 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: -0.83
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rRNA processing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRP1 as an antibody target. Whether an autoantibody or antibody against RRP1 could matter depends on whether native RRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...