CNBP

Protein identityUniProt · HPA

UniProt accession

P62633

Gene

CNBP

Ensembl

ENSG00000169714

Chromosome

3

Canonical length

177 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>P62633|CNBP
     1  MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL PDICYRCGES
    61  GHLAKDCDLQ EDACYNCGRG GHIAKDCKEP KREREQCCYN CGKPGHLARD CDHADEQKCY
   121  SCGEFGHIQK DCTKVKCYRC GETGHVAINC SKTSEVNCYR CGESGHLARE CTIEATA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

1,164 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CNBP.

Disease | AllUniProt

Conditions CNBP is implicated in, by any mechanism.

• Dystrophia myotonica 2 (DM2) MIM:602668

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 29 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Myotonic dystrophy type 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.3

gnomAD pLI

0.96

gnomAD missense Z

2.38

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cholesterol homeostasis
• negative regulation of transcription by RNA polymerase II
• positive regulation of cell population proliferation
• positive regulation of cytoplasmic translation
• positive regulation of DNA-templated transcription
• positive regulation of transcription by RNA polymerase II
• regulation of DNA-templated transcription
• G-quadruplex DNA formation

Molecular functions

• G-quadruplex DNA binding
• mRNA binding
• RNA binding
• single-stranded RNA binding
• translation regulator activity
• zinc ion binding

Cellular components

• cytoplasm
• cytosol
• endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, CCHC-type
• Zinc finger, CCHC-type superfamily
• Zinc knuckle

KeywordsUniProt

• Acetylation
• Cytoplasm
• DNA-binding
• Endoplasmic reticulum
• Metal-binding
• Methylation
• Nucleus
• Phosphoprotein
• Repeat
• Repressor
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of CNBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BRIX1
• EBNA1BP2
• RPL36
• RSL1D1