REEP5
Receptor expression-enhancing protein 5
Also known as: C5orf18, D5S346, DP1, POB16, REEP5_HUMAN, TB2, Yip2e
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q00765
- Gene
- REEP5
- Ensembl
- ENSG00000129625
- Chromosome
- 5
- Canonical length
- 189 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum
- Quaternary structure
- Homotrimer
OverviewNCBI Gene
Predicted to be involved in endoplasmic reticulum membrane organization and regulation of intracellular transport. Located in endoplasmic reticulum tubular network. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
189 residues, UniProt reviewed canonical sequence.
>Q00765|REEP5
1 MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV FGYGASLLCN
61 LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE FFSDIFLSWF PFYYMLKCGF
121 LLWCMAPSPS NGAELLYKRI IRPFFLKHES QMDSVVKDLK DKAKETADAI TKEAKKATVN
181 LLGEEKKSTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against REEP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 224 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 224 nTPM
- cerebral cortex: 174 nTPM
- salivary gland: 139 nTPM
- kidney: 138 nTPM
- parathyroid gland: 132 nTPM
- heart muscle: 125 nTPM
Single-cell type
- syncytiotrophoblasts: 614 nCPM
- extravillous trophoblasts: 470 nCPM
- late primary spermatocytes: 457 nCPM
- breast lactating cells: 385 nCPM
- cytotrophoblasts: 359 nCPM
- pancreatic acinar cells: 356 nCPM
Immune cell
- non-classical monocyte: 318 nTPM
- neutrophil: 255 nTPM
- intermediate monocyte: 250 nTPM
- total PBMC: 237 nTPM
- eosinophil: 235 nTPM
- basophil: 225 nTPM
Brain region
- thalamus: 204 nTPM
- cerebral cortex: 193 nTPM
- pons: 192 nTPM
- hypothalamus: 185 nTPM
- medulla oblongata: 173 nTPM
- midbrain: 173 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about REEP5.
Disease | ImmuneIEDB
Conditions an epitope on REEP5 was assayed in.
- skin melanoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.27
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.08
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of REEP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads REEP5 as an antibody target. Whether an autoantibody or antibody against REEP5 could matter depends on whether native REEP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
REEP5 is annotated at the cell surface, where native REEP5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label REEP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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