Seroatlas · Human Serome Atlas

REEP4

Receptor expression-enhancing protein 4

Also known as: C8orf20, FLJ22246, FLJ22277, PP432, REEP4_HUMAN, Yip2c

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6H4
Gene: REEP4
Ensembl: ENSG00000168476
Chromosome: 8
Canonical length: 257 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Involved in mitotic nuclear membrane reassembly. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q9H6H4|REEP4
     1  MVSWMICRLV VLVFGMLCPA YASYKAVKTK NIREYVRWMM YWIVFALFMA AEIVTDIFIS
    61  WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE KEIDAYIVQA KERSYETVLS
   121  FGKRGLNIAA SAAVQAATKS QGALAGRLRS FSMQDLRSIS DAPAPAYHDP LYLEDQVSHR
   181  RPPIGYRAGG LQDSDTEDEC WSDTEAVPRA PARPREKPLI RSQSLRVVKR KPPVREGTSR
   241  SLKVRTRKKT VPSDVDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REEP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

skin: 92 nTPM
esophagus: 90 nTPM
vagina: 50 nTPM
testis: 43 nTPM
cervix: 37 nTPM
spleen: 34 nTPM

Single-cell type

esophageal apical cells: 351 nCPM
esophageal suprabasal cells: 160 nCPM
syncytiotrophoblasts: 118 nCPM
late primary spermatocytes: 116 nCPM
esophageal basal cells: 88 nCPM
migrating cytotrophoblasts: 66 nCPM

Immune cell

eosinophil: 64 nTPM
classical monocyte: 55 nTPM
intermediate monocyte: 54 nTPM
basophil: 50 nTPM
myeloid DC: 43 nTPM
non-classical monocyte: 37 nTPM

Brain region

white matter: 17 nTPM
medulla oblongata: 16 nTPM
thalamus: 13 nTPM
pons: 13 nTPM
spinal cord: 12 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.03
gnomAD missense Z: 0.45
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of REEP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REEP4 as an antibody target. Whether an autoantibody or antibody against REEP4 could matter depends on whether native REEP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REEP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REEP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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