Seroatlas · Human Serome Atlas

GOLT1B

Vesicle transport protein GOT1B

Also known as: CGI-141, GOT1, GOT1B_HUMAN, YMR292W

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3E0
Gene: GOLT1B
Ensembl: ENSG00000111711
Chromosome: 12
Canonical length: 138 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>Q9Y3E0|GOLT1B
     1  MISLTDTQKI GMGLTGFGVF FLFFGMILFF DKALLAIGNV LFVAGLAFVI GLERTFRFFF
    61  QKHKMKATGF FLGGVFVVLI GWPLIGMIFE IYGFFLLFRG FFPVVVGFIR RVPVLGSLLN
   121  LPGIRSFVDK VGESNNMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLT1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

placenta: 27 nTPM
bone marrow: 24 nTPM
cerebellum: 22 nTPM
adrenal gland: 21 nTPM
pancreas: 20 nTPM
liver: 18 nTPM

Single-cell type

esophageal apical cells: 133 nCPM
extravillous trophoblasts: 122 nCPM
syncytiotrophoblasts: 93 nCPM
plasma cells: 86 nCPM
gastric progenitor cells: 72 nCPM
brain excitatory neurons: 70 nCPM

Immune cell

basophil: 49 nTPM
intermediate monocyte: 32 nTPM
non-classical monocyte: 30 nTPM
plasmacytoid DC: 30 nTPM
T-reg: 28 nTPM
total PBMC: 28 nTPM

Brain region

white matter: 24 nTPM
hypothalamus: 22 nTPM
midbrain: 21 nTPM
thalamus: 20 nTPM
pons: 19 nTPM
spinal cord: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.85
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOLT1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLT1B as an antibody target. Whether an autoantibody or antibody against GOLT1B could matter depends on whether native GOLT1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLT1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLT1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...