Seroatlas · Human Serome Atlas

DERL2

Derlin-2

Also known as: CGI-101, DERL2_HUMAN, derlin-2, F-LAN-1, F-LANa, FLANa

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZP9
Gene: DERL2
Ensembl: ENSG00000072849
Chromosome: 17
Canonical length: 239 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q9GZP9|DERL2
     1  MAYQSLRLEY LQIPPVSRAY TTACVLTTAA VQLELITPFQ LYFNPELIFK HFQIWRLITN
    61  FLFFGPVGFN FLFNMIFLYR YCRMLEEGSF RGRTADFVFM FLFGGFLMTL FGLFVSLVFL
   121  GQAFTIMLVY VWSRRNPYVR MNFFGLLNFQ APFLPWVLMG FSLLLGNSII VDLLGIAVGH
   181  IYFFLEDVFP NQPGGIRILK TPSILKAIFD TPDEDPNYNP LPEERPGGFA WGEGQRLGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DERL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 32 nTPM
epididymis: 28 nTPM
salivary gland: 27 nTPM
pancreas: 26 nTPM
liver: 25 nTPM
thyroid gland: 23 nTPM

Single-cell type

late primary spermatocytes: 306 nCPM
early spermatids: 217 nCPM
esophageal apical cells: 157 nCPM
epididymal principal cells: 143 nCPM
extravillous trophoblasts: 142 nCPM
plasma cells: 127 nCPM

Immune cell

total PBMC: 118 nTPM
T-reg: 81 nTPM
eosinophil: 77 nTPM
basophil: 72 nTPM
intermediate monocyte: 71 nTPM
plasmacytoid DC: 69 nTPM

Brain region

white matter: 11 nTPM
choroid plexus: 11 nTPM
pons: 9.7 nTPM
medulla oblongata: 9.5 nTPM
midbrain: 9.4 nTPM
hypothalamus: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.96
gnomAD missense Z: 1.62
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DERL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DERL2 as an antibody target. Whether an autoantibody or antibody against DERL2 could matter depends on whether native DERL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DERL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DERL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...