PRAF2
PRA1 family protein 2
Also known as: JM4, PRAF2_HUMAN, Yip6a
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O60831
- Gene
- PRAF2
- Ensembl
- ENSG00000243279
- Chromosome
- X
- Canonical length
- 178 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Endoplasmic reticulum,Vesicles
OverviewNCBI Gene
Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in endosome membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynapse. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
178 residues, UniProt reviewed canonical sequence.
>O60831|PRAF2
1 MSEVRLPPLR ALDDFVLGSA RLAAPDPCDP QRWCHRVINN LLYYQTNYLL CFGIGLALAG
61 YVRPLHTLLS ALVVAVALGV LVWAAETRAA VRRCRRSHPA ACLAAVLAVG LLVLWVAGGA
121 CTFLFSIAGP VLLILVHASL RLRNLKNKIE NKIESIGLKR TPMGLLLEAL GQEQEAGSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRAF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 154 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 154 nTPM
- choroid plexus: 88 nTPM
- pituitary gland: 76 nTPM
- hypothalamus: 71 nTPM
- cerebral cortex: 66 nTPM
- midbrain: 65 nTPM
Single-cell type
- epididymal principal cells: 264 nCPM
- decidual stromal cells: 156 nCPM
- hepatic stellate cells: 65 nCPM
- ovarian stromal cells: 35 nCPM
- peritubular myoid cells: 33 nCPM
- leydig cells: 31 nCPM
Immune cell
- T-reg: 69 nTPM
- basophil: 47 nTPM
- MAIT T-cell: 43 nTPM
- memory CD4 T-cell: 42 nTPM
- naive CD8 T-cell: 40 nTPM
- NK-cell: 39 nTPM
Brain region
- pons: 73 nTPM
- midbrain: 73 nTPM
- hypothalamus: 68 nTPM
- thalamus: 66 nTPM
- medulla oblongata: 63 nTPM
- white matter: 62 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.67
- gnomAD pLI
- 0.74
- gnomAD missense Z
- 1.17
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PRAF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRAF2 as an antibody target. Whether an autoantibody or antibody against PRAF2 could matter depends on whether native PRAF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRAF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PRAF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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