Seroatlas · Human Serome Atlas

SCAMP2

Secretory carrier-associated membrane protein 2

Also known as: SCAM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15127
Gene
SCAMP2
Ensembl
ENSG00000140497
Chromosome
15
Canonical length
329 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles,Mid piece,Principal piece

OverviewNCBI Gene

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>O15127|SCAMP2
     1  MSAFDTNPFA DPVDVNPFQD PSVTQLTNAP QGGLAEFNPF SETNAATTVP VTQLPGSSQP
    61  AVLQPSVEPT QPTPQAVVSA AQAGLLRQQE ELDRKAAELE RKERELQNTV ANLHVRQNNW
   121  PPLPSWCPVK PCFYQDFSTE IPADYQRICK MLYYLWMLHS VTLFLNLLAC LAWFSGNSSK
   181  GVDFGLSILW FLIFTPCAFL CWYRPIYKAF RSDNSFSFFV FFFVFFCQIG IYIIQLVGIP
   241  GLGDSGWIAA LSTLDNHSLA ISVIMMVVAG FFTLCAVLSV FLLQRVHSLY RRTGASFQQA
   301  QEEFSQGIFS SRTFHRAASS AAQGAFQGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCAMP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
99 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 99 nTPM
  • salivary gland: 87 nTPM
  • parathyroid gland: 81 nTPM
  • small intestine: 76 nTPM
  • colon: 71 nTPM
  • duodenum: 71 nTPM

Single-cell type

  • esophageal apical cells: 395 nCPM
  • hofbauer cells: 225 nCPM
  • cytotrophoblasts: 211 nCPM
  • alveolar cells type 1: 186 nCPM
  • syncytiotrophoblasts: 173 nCPM
  • esophageal suprabasal cells: 156 nCPM

Immune cell

  • plasmacytoid DC: 129 nTPM
  • total PBMC: 121 nTPM
  • non-classical monocyte: 120 nTPM
  • basophil: 119 nTPM
  • classical monocyte: 111 nTPM
  • intermediate monocyte: 107 nTPM

Brain region

  • medulla oblongata: 60 nTPM
  • choroid plexus: 56 nTPM
  • white matter: 48 nTPM
  • spinal cord: 46 nTPM
  • thalamus: 45 nTPM
  • pons: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.16
gnomAD missense Z
1.3
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCAMP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCAMP2 as an antibody target. Whether an autoantibody or antibody against SCAMP2 could matter depends on whether native SCAMP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCAMP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCAMP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCAMP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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