Seroatlas · Human Serome Atlas

PLAGL2

Zinc finger protein PLAGL2

Also known as: PLAL2_HUMAN, ZNF900

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UPG8
Gene: PLAGL2
Ensembl: ENSG00000126003
Chromosome: 20
Canonical length: 496 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q9UPG8|PLAGL2
     1  MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS NGEKLRPHSL
    61  PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC MYCDKMFHRK DHLRNHLQTH
   121  DPNKEALHCS ECGKNYNTKL GYRRHLAMHA ASSGDLSCKV CLQTFESTQA LLEHLKAHSR
   181  RVAGGAKEKK HPCDHCDRRF YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK
   241  SHSQELLKIK TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA
   301  HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL PDKLPKVEVD
   361  SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP ANLSEALCAA NVDFSHLLGF
   421  LPLNLPPCNP PGATGGLVMG YSQAEAQPLL TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT
   481  SGLSSTTLPR FHQAFQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLAGL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 30 nTPM
testis: 16 nTPM
esophagus: 13 nTPM
small intestine: 12 nTPM
retina: 12 nTPM
tonsil: 10 nTPM

Single-cell type

late spermatids: 265 nCPM
early spermatids: 62 nCPM
endometrial glandular cells: 59 nCPM
esophageal apical cells: 53 nCPM
endometrial luminal cells: 53 nCPM
neutrophil progenitors: 42 nCPM

Immune cell

non-classical monocyte: 35 nTPM
intermediate monocyte: 18 nTPM
classical monocyte: 3.6 nTPM
total PBMC: 2.5 nTPM
basophil: 2.2 nTPM
myeloid DC: 2.2 nTPM

Brain region

choroid plexus: 15 nTPM
basal ganglia: 10 nTPM
hippocampal formation: 9.6 nTPM
cerebellum: 9.5 nTPM
cerebral cortex: 9 nTPM
medulla oblongata: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.98
gnomAD missense Z: 2.11
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLAGL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RCHY1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLAGL2 as an antibody target. Whether an autoantibody or antibody against PLAGL2 could matter depends on whether native PLAGL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLAGL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLAGL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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