Seroatlas · Human Serome Atlas

AIG1

Androgen-induced gene 1 protein

Also known as: AIG-1, AIG1_HUMAN, dJ95L4.1, FLJ10485

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVV5
Gene: AIG1
Ensembl: ENSG00000146416
Chromosome: 6
Canonical length: 238 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Enables hydrolase activity. Involved in long-chain fatty acid catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q9NVV5|AIG1
     1  MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ AVFFGICVLT
    61  DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF VVAVFWIIYA YDREMIYPKL
   121  LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH QYPSRSSGLT AICTFSVGYI LWVCWVHHVT
   181  GMWVYPFLEH IGPGARIIFF GSTTILMNFL YLLGEVLNNY IWDTQKSMEE EKEKPKLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 220 nTPM

Expression across tissuesHPA

Tissue

liver: 220 nTPM
kidney: 95 nTPM
choroid plexus: 53 nTPM
spinal cord: 51 nTPM
duodenum: 44 nTPM
small intestine: 43 nTPM

Single-cell type

esophageal apical cells: 527 nCPM
proximal tubule cells: 420 nCPM
hepatocytes: 418 nCPM
enterocytes: 354 nCPM
myonuclei: 324 nCPM
cardiomyocytes: 301 nCPM

Immune cell

non-classical monocyte: 36 nTPM
myeloid DC: 33 nTPM
intermediate monocyte: 30 nTPM
MAIT T-cell: 15 nTPM
naive CD4 T-cell: 13 nTPM
memory CD4 T-cell: 13 nTPM

Brain region

white matter: 79 nTPM
hypothalamus: 77 nTPM
spinal cord: 72 nTPM
pons: 70 nTPM
thalamus: 67 nTPM
medulla oblongata: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

long-chain fatty acid catabolic process

Molecular functions

hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RCHY1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIG1 as an antibody target. Whether an autoantibody or antibody against AIG1 could matter depends on whether native AIG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIG1 is annotated at the cell surface, where native AIG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AIG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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