Seroatlas · Human Serome Atlas

COPE

Coatomer subunit epsilon

Also known as: COPE_HUMAN, epsilon-COP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14579
Gene
COPE
Ensembl
ENSG00000105669
Chromosome
19
Canonical length
308 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>O14579|COPE
     1  MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV ERDVFLYRAY
    61  LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI VAELDREMSR SVDVTNTTFL
   121  LMAASIYLHD QNPDAALRAL HQGDSLECTA MTVQILLKLD RLDLARKELK RMQDLDEDAT
   181  LTQLATAWVS LATGGEKLQD AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGLLQ
   241  EALDKDSGYP ETLVNLIVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY QAKENDFDRL
   301  VLQYAPSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
186 nTPM

Expression across tissuesHPA

Tissue

  • liver: 186 nTPM
  • midbrain: 179 nTPM
  • basal ganglia: 176 nTPM
  • spinal cord: 173 nTPM
  • testis: 169 nTPM
  • amygdala: 165 nTPM

Single-cell type

  • esophageal apical cells: 1,003 nCPM
  • oocytes: 811 nCPM
  • syncytiotrophoblasts: 669 nCPM
  • esophageal suprabasal cells: 571 nCPM
  • extravillous trophoblasts: 567 nCPM
  • epididymal principal cells: 564 nCPM

Immune cell

  • total PBMC: 930 nTPM
  • plasmacytoid DC: 661 nTPM
  • basophil: 659 nTPM
  • eosinophil: 641 nTPM
  • classical monocyte: 600 nTPM
  • neutrophil: 597 nTPM

Brain region

  • white matter: 156 nTPM
  • medulla oblongata: 138 nTPM
  • cerebellum: 135 nTPM
  • spinal cord: 130 nTPM
  • thalamus: 130 nTPM
  • midbrain: 120 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.69
gnomAD missense Z
0.28
DepMap mean gene effect
-1.12
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPE as an antibody target. Whether an autoantibody or antibody against COPE could matter depends on whether native COPE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...