Seroatlas · Human Serome Atlas

GORAB

RAB6-interacting golgin

Also known as: FLJ11752, GO, GORAB_HUMAN, NTKL-BP1, SCYL1BP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T7V8
Gene
GORAB
Ensembl
ENSG00000120370
Chromosome
1
Canonical length
369 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q5T7V8|GORAB
     1  MAQGWAGFSE EELRRLKQTK DPFEPQRRLP AKKSRQQLQR EKALVEQSQK LGLQDGSTSL
    61  LPEQLLSAPK QRVNVQKPPF SSPTLPSHFT LTSPVGDGQP QGIESQPKEL GLENSHDGHN
   121  NVEILPPKPD CKLEKKKVEL QEKSRWEVLQ QEQRLMEEKN KRKKALLAKA IAERSKRTQA
   181  ETMKLKRIQK ELQALDDMVS ADIGILRNRI DQASLDYSYA RKRFDRAEAE YIAAKLDIQR
   241  KTEIKEQLTE HLCTIIQQNE LRKAKKLEEL MQQLDVEADE ETLELEVEVE RLLHEQEVES
   301  RRPVVRLERP FQPAEESVTL EFAKENRKCQ EQAVSPKVDD QCGNSSSIPF LSPNCPNQEG
   361  NDISAALAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GORAB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
3.2 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 3.2 nTPM
  • cervix: 3.1 nTPM
  • epididymis: 3.1 nTPM
  • ovary: 3.1 nTPM
  • lymph node: 3 nTPM
  • tonsil: 2.9 nTPM

Single-cell type

  • pancreatic duct cells: 45 nCPM
  • somatotrophs: 37 nCPM
  • lactotrophs: 33 nCPM
  • leydig cells: 31 nCPM
  • sertoli cells: 31 nCPM
  • cardiomyocytes: 29 nCPM

Immune cell

  • T-reg: 5.1 nTPM
  • NK-cell: 3.9 nTPM
  • intermediate monocyte: 3.8 nTPM
  • memory CD4 T-cell: 3.8 nTPM
  • MAIT T-cell: 3.5 nTPM
  • classical monocyte: 3.2 nTPM

Brain region

  • hypothalamus: 2 nTPM
  • white matter: 1.3 nTPM
  • medulla oblongata: 1.2 nTPM
  • midbrain: 1.2 nTPM
  • choroid plexus: 1.1 nTPM
  • spinal cord: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GORAB.

Disease | AllUniProt

Conditions GORAB is implicated in, by any mechanism.

Disease | GeneticClinVar

49 pathogenic / likely-pathogenic of 425 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
-0.18
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • RAB6-interacting golgin
  • Transcriptional activator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GORAB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GORAB as an antibody target. Whether an autoantibody or antibody against GORAB could matter depends on whether native GORAB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GORAB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GORAB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GORAB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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