Seroatlas · Human Serome Atlas

NDRG1

Protein NDRG1

Also known as: CAP43, DRG1, NDR1, NDRG1_HUMAN, RTP, TDD5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92597
Gene
NDRG1
Ensembl
ENSG00000104419
Chromosome
8
Canonical length
394 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Microtubules,Cytosol,Calyx,Connecting piece,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q92597|NDRG1
     1  MSREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL
    61  TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE
   121  MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI
   181  SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE
   241  RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK
   301  LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT
   361  RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
472 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 472 nTPM
  • esophagus: 348 nTPM
  • midbrain: 344 nTPM
  • prostate: 333 nTPM
  • vagina: 311 nTPM
  • skin: 292 nTPM

Single-cell type

  • suprabasal keratinocytes: 858 nCPM
  • esophageal apical cells: 751 nCPM
  • esophageal suprabasal cells: 650 nCPM
  • prostatic hillock cells: 518 nCPM
  • ocular epithelial cells: 493 nCPM
  • renal connecting tubule cells: 412 nCPM

Immune cell

  • plasmacytoid DC: 13 nTPM
  • basophil: 11 nTPM
  • MAIT T-cell: 9.1 nTPM
  • T-reg: 8.1 nTPM
  • memory CD8 T-cell: 6.9 nTPM
  • myeloid DC: 6 nTPM

Brain region

  • white matter: 1,114 nTPM
  • medulla oblongata: 972 nTPM
  • basal ganglia: 952 nTPM
  • midbrain: 918 nTPM
  • pons: 862 nTPM
  • thalamus: 759 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NDRG1.

Disease | AllUniProt

Conditions NDRG1 is implicated in, by any mechanism.

  • Charcot-Marie-Tooth disease, demyelinating, type 4D (CMT4D) MIM:601455

Disease | GeneticClinVar

51 pathogenic / likely-pathogenic of 924 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.01
gnomAD missense Z
0.65
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDRG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDRG1 as an antibody target. Whether an autoantibody or antibody against NDRG1 could matter depends on whether native NDRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDRG1 is annotated at the cell surface, where native NDRG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NDRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDRG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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