Seroatlas · Human Serome Atlas

DENND1C

DENN domain-containing protein 1C

Also known as: DEN1C_HUMAN, FAM31C, FLJ22757

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IV53
Gene: DENND1C
Ensembl: ENSG00000205744
Chromosome: 19
Canonical length: 801 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

The protein encoded by this gene functions as a guanine nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in actin polymerization. The encoded protein activates RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This gene may play a role in linking RAB35 activation with the clathrin machinery. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

801 residues, UniProt reviewed canonical sequence.

>Q8IV53|DENND1C
     1  MESRAEGGSP AVFDWFFEAA CPASLQEDPP ILRQFPPDFR DQEAMQMVPK FCFPFDVERE
    61  PPSPAVQHFT FALTDLAGNR RFGFCRLRAG TQSCLCILSH LPWFEVFYKL LNTVGDLLAQ
   121  DQVTEAEELL QNLFQQSLSG PQASVGLELG SGVTVSSGQG IPPPTRGNSK PLSCFVAPDS
   181  GRLPSIPENR NLTELVVAVT DENIVGLFAA LLAERRVLLT ASKLSTLTSC VHASCALLYP
   241  MRWEHVLIPT LPPHLLDYCC APMPYLIGVH ASLAERVREK ALEDVVVLNV DANTLETTFN
   301  DVQALPPDVV SLLRLRLRKV ALAPGEGVSR LFLKAQALLF GGYRDALVCS PGQPVTFSEE
   361  VFLAQKPGAP LQAFHRRAVH LQLFKQFIEA RLEKLNKGEG FSDQFEQEIT GCGASSGALR
   421  SYQLWADNLK KGGGALLHSV KAKTQPAVKN MYRSAKSGLK GVQSLLMYKD GDSVLQRGGS
   481  LRAPALPSRS DRLQQRLPIT QHFGKNRPLR PSRRRQLEEG TSEPPGAGTP PLSPEDEGCP
   541  WAEEALDSSF LGSGEELDLL SEILDSLSMG AKSAGSLRPS QSLDCCHRGD LDSCFSLPNI
   601  PRWQPDDKKL PEPEPQPLSL PSLQNASSLD ATSSSKDSRS QLIPSESDQE VTSPSQSSTA
   661  SADPSIWGDP KPSPLTEPLI LHLTPSHKAA EDSTAQENPT PWLSTAPTEP SPPESPQILA
   721  PTKPNFDIAW TSQPLDPSSD PSSLEDPRAR PPKALLAERA HLQPREEPGA LNSPATPTSN
   781  CQKSQPSSRP RVADLKKCFE G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DENND1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

spleen: 34 nTPM
lymph node: 30 nTPM
appendix: 20 nTPM
bone marrow: 20 nTPM
thymus: 19 nTPM
tonsil: 14 nTPM

Single-cell type

nk-cells: 63 nCPM
t-cells: 54 nCPM
neutrophils: 52 nCPM
b-cells: 35 nCPM
thymocytes: 29 nCPM
neutrophil progenitors: 28 nCPM

Immune cell

gdT-cell: 40 nTPM
total PBMC: 37 nTPM
naive CD4 T-cell: 36 nTPM
T-reg: 36 nTPM
non-classical monocyte: 35 nTPM
MAIT T-cell: 35 nTPM

Brain region

thalamus: 4.8 nTPM
white matter: 4.1 nTPM
medulla oblongata: 3.7 nTPM
pons: 3.3 nTPM
cerebral cortex: 2.4 nTPM
midbrain: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DENND1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DENND1C as an antibody target. Whether an autoantibody or antibody against DENND1C could matter depends on whether native DENND1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DENND1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DENND1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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