Seroatlas · Human Serome Atlas

BICDL2

BICD family-like cargo adapter 2

Also known as: BICL2_HUMAN, CCDC64B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1A5D9
Gene: BICDL2
Ensembl: ENSG00000162069
Chromosome: 16
Canonical length: 508 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments,Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>A1A5D9|BICDL2
     1  MSSPDGPSFP SGPLSGGASP SGDEGFFPFV LERRDSFLGG GPGPEEPEDL ALQLQQKEKD
    61  LLLAAELGKM LLERNEELRR QLETLSAQHL EREERLQQEN HELRRGLAAR GAEWEARAVE
   121  LEGDVEALRA QLGEQRSEQQ DSGRERARAL SELSEQNLRL SQQLAQASQT EQELQRELDA
   181  LRGQCQAQAL AGAELRTRLE SLQGENQMLQ SRRQDLEAQI RGLREEVEKG EGRLQTTHEE
   241  LLLLRRERRE HSLELERARS EAGEALSALR RLQRRVSELE EESRLQDADV SAASLQSELA
   301  HSLDDGDQGQ GADAPGDTPT TRSPKTRKAS SPQPSPPEEI LEPPKKRTSL SPAEILEEKE
   361  VEVAKLQDEI SLQQAELQSL REELQRQKEL RAQEDPGEAL HSALSDRDEA VNKALELSLQ
   421  LNRVSLERDS LSRELLRAIR QKVALTQELE AWQDDMQVVI GQQLRSQRQK ELSASASSST
   481  PRRAAPRFSL RLGPGPAGGF LSNLFRRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BICDL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

pancreas: 124 nTPM
esophagus: 102 nTPM
salivary gland: 43 nTPM
skin: 42 nTPM
vagina: 42 nTPM
cervix: 38 nTPM

Single-cell type

esophageal apical cells: 1,247 nCPM
esophageal suprabasal cells: 266 nCPM
colonocytes: 250 nCPM
breast lactating cells: 232 nCPM
prostatic club cells: 187 nCPM
prostatic hillock cells: 166 nCPM

Immune cell

neutrophil: 0.9 nTPM
eosinophil: 0.8 nTPM
basophil: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 2 nTPM
medulla oblongata: 1.4 nTPM
cerebellum: 1.3 nTPM
cerebral cortex: 1.3 nTPM
midbrain: 1 nTPM
thalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

small GTPase binding

Protein domainsUniProt · Pfam · InterPro

Spindly/BICDR Dynein Motor Adapter

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of BICDL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAB13

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BICDL2 as an antibody target. Whether an autoantibody or antibody against BICDL2 could matter depends on whether native BICDL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BICDL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BICDL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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