Seroatlas · Human Serome Atlas

LEPROT

Leptin receptor gene-related protein

Also known as: FLJ90360, OB-RGRP, OBRG_HUMAN, OBRGRP, VPS55

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15243
Gene: LEPROT
Ensembl: ENSG00000213625
Chromosome: 1
Canonical length: 131 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centrosome

OverviewNCBI Gene

LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>O15243|LEPROT
     1  MAGVKALVAL SFSGAIGLTF LMLGCALEDY GVYWPLFVLI FHAISPIPHF IAKRVTYDSD
    61  ATSSACRELA YFFTTGIVVS AFGFPVILAR VAVIKWGACG LVLAGNAVIF LTIQGFFLIF
   121  GRGDDFSWEQ W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LEPROT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

kidney: 71 nTPM
adipose tissue: 66 nTPM
placenta: 66 nTPM
ovary: 62 nTPM
bone marrow: 62 nTPM
lung: 54 nTPM

Single-cell type

platelets: 23 nCPM
esophageal apical cells: 12 nCPM
gastric chief cells: 11 nCPM
syncytiotrophoblasts: 7.4 nCPM
endometrial glandular cells: 6.6 nCPM
epididymal clear cells: 6.1 nCPM

Immune cell

basophil: 91 nTPM
non-classical monocyte: 77 nTPM
classical monocyte: 61 nTPM
eosinophil: 54 nTPM
neutrophil: 51 nTPM
intermediate monocyte: 51 nTPM

Brain region

choroid plexus: 80 nTPM
medulla oblongata: 55 nTPM
thalamus: 52 nTPM
basal ganglia: 47 nTPM
spinal cord: 47 nTPM
hypothalamus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.44
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LEPROT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LEPROT as an antibody target. Whether an autoantibody or antibody against LEPROT could matter depends on whether native LEPROT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LEPROT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LEPROT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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