Seroatlas · Human Serome Atlas

MICALL2

MICAL-like protein 2

Also known as: FLJ23471, JRAB, MGC46023, MICAL-L2, MILK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY33
Gene: MICALL2
Ensembl: ENSG00000164877
Chromosome: 7
Canonical length: 904 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; recycling endosome; and stress fiber. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q8IY33|MICALL2
     1  MAAIRALQQW CRQQCEGYRD VNICNMTTSF RDGLAFCAIL HRHRPDLINF SALKKENIYE
    61  NNKLAFRVAE EHLGIPALLD AEDMVALKVP DRLSILTYVS QYYNYFHGRS PIGGMAGVKR
   121  ASEDSEEEPS GKKAPVQAAK LPSPAPARKP PLSPAQTNPV VQRRNEGAGG PPPKTDQALA
   181  GSLVSSTCGV CGKHVHLVQR HLADGRLYHR SCFRCKQCSC TLHSGAYKAT GEPGTFVCTS
   241  HLPAAASASP KLTGLVPRQP GAMGVDSRTS CSPQKAQEAN KARPSAWEPA AGNSPARASV
   301  PAAPNPAATS ATSVHVRSPA RPSESRLAPT PTEGKVRPRV TNSSPMGWSS AAPCTAAAAS
   361  HPAVPPSAPD PRPATPQGGG APRVAAPQTT LSSSSTSAAT VDPPAWTPSA SRTQQARNKF
   421  FQTSAVPPGT SLSGRGPTPS LVLSKDSSKE QARNFLKQAL SALEEAGAPA PGRPSPATAA
   481  VPSSQPKTEA PQASPLAKPL QSSSPRVLGL PSRMEPPAPL STSSTSQASA LPPAGRRNLA
   541  ESSGVGRVGA GSRPKPEAPM AKGKSTTLTQ DMSTSLQEGQ EDGPAGWRAN LKPVDRRSPA
   601  ERTLKPKEPR ALAEPRAGEA PRKVSGSFAG SVHITLTPVR PDRTPRPASP GPSLPARSPS
   661  PPRRRRLAVP ASLDVCDNWL RPEPPGQEAR VQSWKEEEKK PHLQGKPGRP LSPANVPALP
   721  GETVTSPVRL HPDYLSPEEI QRQLQDIERR LDALELRGVE LEKRLRAAEG DDAEDSLMVD
   781  WFWLIHEKQL LLRQESELMY KSKAQRLEEQ QLDIEGELRR LMAKPEALKS LQERRREQEL
   841  LEQYVSTVND RSDIVDSLDE DRLREQEEDQ MLRDMIEKLG LQRKKSKFRL SKIWSPKSKS
   901  SPSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICALL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

small intestine: 18 nTPM
adrenal gland: 18 nTPM
spleen: 15 nTPM
colon: 13 nTPM
stomach: 13 nTPM
duodenum: 12 nTPM

Single-cell type

foveolar cells: 180 nCPM
bergmann glia: 158 nCPM
astrocytes: 135 nCPM
oocytes: 129 nCPM
enterocytes: 114 nCPM
colonocytes: 107 nCPM

Immune cell

classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
myeloid DC: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 17 nTPM
midbrain: 16 nTPM
thalamus: 15 nTPM
amygdala: 14 nTPM
hippocampal formation: 13 nTPM
white matter: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MICALL2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 322 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Joubert syndrome 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: -1.99
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MICALL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICALL2 as an antibody target. Whether an autoantibody or antibody against MICALL2 could matter depends on whether native MICALL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICALL2 is annotated at the cell surface, where native MICALL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MICALL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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