Seroatlas · Human Serome Atlas

LEPROTL1

Leptin receptor overlapping transcript-like 1

Also known as: LERL1_HUMAN, my047, Vps55

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95214
Gene: LEPROTL1
Ensembl: ENSG00000104660
Chromosome: 8
Canonical length: 131 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>O95214|LEPROTL1
     1  MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC IARRLVDDTD
    61  AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA LVLTGNTVIF ATILGFFLVF
   121  GSNDDFSWQQ W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LEPROTL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

placenta: 71 nTPM
thymus: 62 nTPM
bone marrow: 53 nTPM
adrenal gland: 44 nTPM
lymph node: 37 nTPM
liver: 35 nTPM

Single-cell type

t-cells: 518 nCPM
gastric progenitor cells: 296 nCPM
nk-cells: 268 nCPM
late primary spermatocytes: 258 nCPM
innate lymphoid cells: 242 nCPM
mast cells: 190 nCPM

Immune cell

naive CD4 T-cell: 350 nTPM
T-reg: 341 nTPM
total PBMC: 285 nTPM
naive CD8 T-cell: 262 nTPM
basophil: 255 nTPM
memory CD4 T-cell: 248 nTPM

Brain region

cerebellum: 44 nTPM
cerebral cortex: 43 nTPM
hippocampal formation: 43 nTPM
white matter: 41 nTPM
basal ganglia: 39 nTPM
hypothalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.72
gnomAD missense Z: 0.94
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LEPROTL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAB13

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LEPROTL1 as an antibody target. Whether an autoantibody or antibody against LEPROTL1 could matter depends on whether native LEPROTL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LEPROTL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LEPROTL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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