Seroatlas · Human Serome Atlas

GATA2

Endothelial transcription factor GATA-2

Also known as: GATA2_HUMAN, NFE1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23769
Gene
GATA2
Ensembl
ENSG00000179348
Chromosome
3
Canonical length
480 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>P23769|GATA2
     1  MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY
    61  ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP
   121  FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE
   181  VSPDPSTTGA ASPASSSAGG SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP
   241  ATHHPIPTYP SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
   301  TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW
   361  RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC
   421  MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GATA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 59 nTPM
  • fallopian tube: 52 nTPM
  • prostate: 50 nTPM
  • endometrium: 45 nTPM
  • cervix: 37 nTPM
  • urinary bladder: 33 nTPM

Single-cell type

  • mast cells: 770 nCPM
  • syncytiotrophoblasts: 368 nCPM
  • extravillous trophoblasts: 356 nCPM
  • prostatic club cells: 280 nCPM
  • megakaryocyte progenitors: 268 nCPM
  • endometrial luminal cells: 207 nCPM

Immune cell

  • basophil: 567 nTPM
  • total PBMC: 3.9 nTPM
  • eosinophil: 1.5 nTPM
  • neutrophil: 0.4 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • myeloid DC: 0.1 nTPM

Brain region

  • midbrain: 38 nTPM
  • thalamus: 25 nTPM
  • medulla oblongata: 23 nTPM
  • pons: 21 nTPM
  • amygdala: 20 nTPM
  • cerebral cortex: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GATA2.

Disease | AllUniProt

Conditions GATA2 is implicated in, by any mechanism.

Disease | GeneticClinVar

230 pathogenic / likely-pathogenic of 1,845 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
2.04
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GATA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GATA2 as an antibody target. Whether an autoantibody or antibody against GATA2 could matter depends on whether native GATA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GATA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GATA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GATA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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