PTPRN

Protein identityUniProt · HPA

UniProt accession

Q16849

Gene

PTPRN

Ensembl

ENSG00000054356

Chromosome

2

Canonical length

979 aa

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Endoplasmic reticulum

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

979 residues, UniProt reviewed canonical sequence.

>Q16849|PTPRN
     1  MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG
    61  QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE
   121  PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL
   181  LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA
   241  PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG
   301  SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL
   361  LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE
   421  VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP
   481  LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE
   541  LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV
   601  RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ
   661  FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ
   721  AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY
   781  IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV
   841  SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG
   901  RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE
   961  FALTAVAEEV NAILKALPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

178 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTPRN.

Disease | ImmuneIEDB

Conditions an epitope on PTPRN was assayed in.

• type 1 diabetes mellitus B and T cell
• type 2 diabetes mellitus T cell
• latent autoimmune diabetes in adults B cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against PTPRN are reported. Each links to that disease's full target list.

• Diabetes Mellitus, Type 1 312
• Diabetes Mellitus, Type 2 54
• Polyendocrinopathies, Autoimmune 5
• Thyroiditis, Autoimmune 5
• Celiac Disease 4
• Obesity 4
• Insulin Resistance 3
• Stiff-Person Syndrome 3

Showing 8 of 16 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for PTPRN from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.58

gnomAD pLI

0

gnomAD missense Z

1.6

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• dense core granule maturation
• insulin secretion
• insulin secretion involved in cellular response to glucose stimulus
• luteinization
• positive regulation of transcription by RNA polymerase II
• positive regulation of type B pancreatic cell proliferation
• regulation of secretion
• response to reactive oxygen species

Molecular functions

• spectrin binding
• transcription factor binding
• ubiquitin-like protein ligase binding

Cellular components

• axon terminus
• endosome
• Golgi apparatus
• neuronal cell body
• nucleus
• perikaryon
• plasma membrane
• secretory granule
• synapse
• transport vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• Tyrosine-specific protein phosphatase, PTPase domain
• Tyrosine-specific protein phosphatases domain
• Protein-tyrosine phosphatase, catalytic
• Protein-tyrosine phosphatase, active site
• Protein-tyrosine phosphatase receptor IA-2 ectodomain
• Protein-tyrosine phosphatase-like
• RESP18 domain
• Receptor-type tyrosine-protein phosphatase-like N/N2
• Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily
• Protein-tyrosine phosphatase
• Protein-tyrosine phosphatase receptor IA-2
• RESP18 domain

KeywordsUniProt

• Cell membrane
• Cell projection
• Cytoplasmic vesicle
• Diabetes mellitus
• Disulfide bond
• Endosome
• Glycoprotein
• Isopeptide bond
• Membrane
• Nucleus
• Phosphoprotein
• Receptor
• Signal
• Synapse
• Transcription
• Transcription regulation
• Transmembrane
• Transmembrane helix
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of PTPRN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PIAS4
• PTPRA
• PTPRE
• PTPRN2
• SNX19
• STAT5B
• HSPA5
• MADD
• PPIA
• PTPRS
• SPTBN4
• SPTLC2