Seroatlas · Human Serome Atlas

ESRRA

Steroid hormone receptor ERR1

Also known as: ERR1, ERR1_HUMAN, ERRa, ERRalpha, ESRL1, NR3B1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P11474
Gene: ESRRA
Ensembl: ENSG00000173153
Chromosome: 11
Canonical length: 423 aa
Protein class: Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Microtubules,Cytokinetic bridge
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>P11474|ESRRA
     1  MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH KEEEDGEGAG
    61  PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE
   121  CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP
   181  LAVAGGPRKT AAPVNALVSH LLVVEPEKLY AMPDPAGPDG HLPAVATLCD LFDREIVVTI
   241  SWAKSIPGFS SLSLSDQMSV LQSVWMEVLV LGVAQRSLPL QDELAFAEDL VLDEEGARAA
   301  GLGELGAALL QLVRRLQALR LEREEYVLLK ALALANSDSV HIEDAEAVEQ LREALHEALL
   361  EYEAGRAGPG GGAERRRAGR LLLTLPLLRQ TAGKVLAHFY GVKLEGKVPM HKLFLEMLEA
   421  MMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ESRRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 180 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 180 nTPM
heart muscle: 140 nTPM
liver: 86 nTPM
tongue: 83 nTPM
duodenum: 77 nTPM
kidney: 68 nTPM

Single-cell type

enterocytes: 213 nCPM
colonocytes: 199 nCPM
syncytiotrophoblasts: 144 nCPM
cytotrophoblasts: 137 nCPM
enteric transient amplifying cells: 131 nCPM
foveolar cells: 115 nCPM

Immune cell

intermediate monocyte: 5.4 nTPM
neutrophil: 5.3 nTPM
non-classical monocyte: 5.2 nTPM
eosinophil: 4.8 nTPM
T-reg: 3.6 nTPM
naive CD8 T-cell: 3.3 nTPM

Brain region

thalamus: 57 nTPM
cerebellum: 55 nTPM
choroid plexus: 49 nTPM
hypothalamus: 45 nTPM
midbrain: 45 nTPM
medulla oblongata: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ESRRA.

Disease | ImmuneIEDB

Conditions an epitope on ESRRA was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.6
gnomAD missense Z: 2.08
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ESRRA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ESRRA as an antibody target. Whether an autoantibody or antibody against ESRRA could matter depends on whether native ESRRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ESRRA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ESRRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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