Seroatlas · Human Serome Atlas

IMMT

MICOS complex subunit MIC60

Also known as: HMP, Mic60, MIC60_HUMAN, MICOS60, MINOS2, P87, P89

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16891
Gene: IMMT
Ensembl: ENSG00000132305
Chromosome: 2
Canonical length: 758 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables RNA binding activity. Involved in cristae formation. Located in mitochondrial inner membrane. Part of MICOS complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

758 residues, UniProt reviewed canonical sequence.

>Q16891|IMMT
     1  MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG
    61  TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE
   121  SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK
   181  PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA
   241  AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE
   301  ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE
   361  LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA
   421  EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR
   481  TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN
   541  TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK
   601  ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL
   661  SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV
   721  AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IMMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 270 nTPM

Expression across tissuesHPA

Tissue

tongue: 270 nTPM
skeletal muscle: 187 nTPM
heart muscle: 154 nTPM
parathyroid gland: 85 nTPM
kidney: 76 nTPM
adrenal gland: 75 nTPM

Single-cell type

oocytes: 290 nCPM
myonuclei: 221 nCPM
late spermatids: 206 nCPM
parietal cells: 175 nCPM
erythrocyte progenitors: 168 nCPM
early spermatids: 167 nCPM

Immune cell

intermediate monocyte: 34 nTPM
non-classical monocyte: 33 nTPM
myeloid DC: 33 nTPM
classical monocyte: 29 nTPM
total PBMC: 25 nTPM
gdT-cell: 23 nTPM

Brain region

choroid plexus: 66 nTPM
medulla oblongata: 51 nTPM
pons: 51 nTPM
cerebral cortex: 50 nTPM
hypothalamus: 50 nTPM
midbrain: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.01
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

MICOS complex subunit MIC60
Mitochondrial inner membrane protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IMMT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IMMT as an antibody target. Whether an autoantibody or antibody against IMMT could matter depends on whether native IMMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IMMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IMMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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