Seroatlas · Human Serome Atlas

PARD3B

Partitioning defective 3 homolog B

Also known as: ALS2CR19, PAR3beta, Par3L, PAR3L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEW8
Gene: PARD3B
Ensembl: ENSG00000116117
Chromosome: 2
Canonical length: 1205 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Located in cell junction. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1205 residues, UniProt reviewed canonical sequence.

>Q8TEW8|PARD3B
     1  MKVTVCFGRT GIVVPCKEGQ LRVGELTQQA LQRYLKTREK GPGYWVKIHH LEYTDGGILD
    61  PDDVLADVVE DKDKLIAVFE EQEPLHKIES PSGNPADRQS PDAFETEVAA QLAAFKPIGG
   121  EIEVTPSALK LGTPLLVRRS SDPVPGPPAD TQPSASHPGG QSLKLVVPDS TQNLEDREVL
   181  NGVQTELLTS PRTKDTLSDM TRTVEISGEG GPLGIHVVPF FSSLSGRILG LFIRGIEDNS
   241  RSKREGLFHE NECIVKINNV DLVDKTFAQA QDVFRQAMKS PSVLLHVLPP QNREQYEKSV
   301  IGSLNIFGNN DGVLKTKVPP PVHGKSGLKT ANLTGTDSPE TDASASLQQN KSPRVPRLGG
   361  KPSSPSLSPL MGFGSNKNAK KIKIDLKKGP EGLGFTVVTR DSSIHGPGPI FVKNILPKGA
   421  AIKDGRLQSG DRILEVNGRD VTGRTQEELV AMLRSTKQGE TASLVIARQE GHFLPRELKG
   481  EPDCCALSLE TSEQLTFEIP LNDSGSAGLG VSLKGNKSRE TGTDLGIFIK SIIHGGAAFK
   541  DGRLRMNDQL IAVNGESLLG KSNHEAMETL RRSMSMEGNI RGMIQLVILR RPERPMEDPA
   601  ECGAFSKPCF ENCQNAVTTS RRNDNSILHP LGTCSPQDKQ KGLLLPNDGW AESEVPPSPT
   661  PHSALGLGLE DYSHSSGVDS AVYFPDQHIN FRSVTPARQP ESINLKASKS MDLVPDESKV
   721  HSLAGQKSES PSKDFGPTLG LKKSSSLESL QTAVAEVRKN DLPFHRPRPH MVRGRGCNES
   781  FRAAIDKSYD GPEEIEADGL SDKSSHSGQG ALNCESAPQG NSELEDMENK ARKVKKTKEK
   841  EKKKEKGKLK VKEKKRKEEN EDPERKIKKK GFGAMLRFGK KKEDKGGKAE QKGTLKHGGL
   901  REEELEKMKE ERERIGAKHQ ELREKQARGL LDYATGAIGS VYDMDDDEMD PNYARVNHFR
   961  EPCTSANVFR SPSPPRAGPF GYPRDGHPLS PERDHLEGLY AKVNKPYHPL VPADSGRPTG
  1021  GSTDRIQKLR KEYYQARREG FPLYEDDEGR ARPSEYDLLW VPGRGPDGNA HNLRFEGMER
  1081  QYASLPRGGP ADPVDYLPAA PRGLYKEREL PYYPGAHPMH PPKGSYPRPT ELRVADLRYP
  1141  QHYPPPPAPQ HKGPFRQDVP PSPPQHQRMP AYQETGRPGP RGGSPDQYPY RTQDSRQKNP
  1201  MTAAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARD3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 14 nTPM
colon: 12 nTPM
adipose tissue: 8.7 nTPM
parathyroid gland: 8.7 nTPM
ovary: 8.1 nTPM
urinary bladder: 6.5 nTPM

Single-cell type

podocytes: 4,928 nCPM
ependymal cells: 2,109 nCPM
choroid plexus epithelial cells: 1,154 nCPM
fibro-adipogenic progenitors: 1,069 nCPM
mesothelial cells: 1000 nCPM
astrocytes: 941 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 27 nTPM
medulla oblongata: 21 nTPM
hypothalamus: 21 nTPM
choroid plexus: 19 nTPM
spinal cord: 19 nTPM
basal ganglia: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PARD3B.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 240 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: -0.56
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARD3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARD3B as an antibody target. Whether an autoantibody or antibody against PARD3B could matter depends on whether native PARD3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARD3B is annotated at the cell surface, where native PARD3B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARD3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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