Seroatlas · Human Serome Atlas

COBLL1

Cordon-bleu protein-like 1

Also known as: COBL1_HUMAN, KIAA0977

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53SF7
Gene: COBLL1
Ensembl: ENSG00000082438
Chromosome: 2
Canonical length: 1128 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

Enables cadherin binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1128 residues, UniProt reviewed canonical sequence.

>Q53SF7|COBLL1
     1  MDGRTPRPQD APARRKPKAK APLPPAETKY TDVSSAADSV ESTAFIMEQK ENMIDKDVEL
    61  SVVLPGDIIK STTVHGSKPM MDLLIFLCAQ YHLNPSSYTI DLLSAEQNHI KFKPNTPIGM
   121  LEVEKVILKP KMLDKKKPTP IIPEKTVRVV INFKKTQKTI VRVSPHASLQ ELAPIICSKC
   181  EFDPLHTLLL KDYQSQEPLD LTKSLNDLGL RELYAMDVNR ESCQISQNLD IMKEKENKGF
   241  FSFFQRSKKK RDQTASAPAT PLVNKHRPTF TRSNTISKPY ISNTLPSDAP KKRRAPLPPM
   301  PASQSVPQDL AHIQERPASC IVKSMSVDET DKSPCEAGRV RAGSLQLSSM SAGNSSLRRT
   361  KRKAPSPPSK IPPHQSDENS RVTALQPVDG VPPDSASEAN SPEELSSPAG ISSDYSLEEI
   421  DEKEELSEVP KVEAENISPK SQDIPFVSTD IINTLKNDPD SALGNGSGEF SQNSMEEKQE
   481  TKSTDGQEPH SVVYDTSNGK KVVDSIRNLK SLGPNQENVV QNEIIVYPEN TEDNMKNGVK
   541  KTEINVEGVA KNNNIDMEVE RPSNSEAHET DTAISYKENH LAASSVPDQK LNQPSAEKTK
   601  DAAIQTTPSC NSFDGKHQDH NLSDSKVEEC VQTSNNNIST QHSCLSSQDS VNTSREFRSQ
   661  GTLIIHSEDP LTVKDPICAH GNDDLLPPVD RIDKNSTASY LKNYPLYRQD YNPKPKPSNE
   721  ITREYIPKIG MTTYKIVPPK SLEISKDWQS ETIEYKDDQD MHALGKKHTH ENVKETAIQT
   781  EDSAISESPE EPLPNLKPKP NLRTEHQVPS SVSSPDDAMV SPLKPAPKMT RDTGTAPFAP
   841  NLEEINNILE SKFKSRASNA QAKPSSFFLQ MQKRVSGHYV TSAAAKSVHA APNPAPKELT
   901  NKEAERDMLP SPEQTLSPLS KMPHSVPQPL VEKTDDDVIG QAPAEASPPP IAPKPVTIPA
   961  SQVSTQNLKT LKTFGAPRPY SSSGPSPFAL AVVKRSQSFS KERTESPSAS ALVQPPANTE
  1021  EGKTHSVNKF VDIPQLGVSD KENNSAHNEQ NSQIPTPTDG PSFTVMRQSS LTFQSSDPEQ
  1081  MRQSLLTAIR SGEAAAKLKR VTIPSNTISV NGRSRLSHSM SPDAQDGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COBLL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

liver: 101 nTPM
kidney: 64 nTPM
retina: 53 nTPM
adrenal gland: 49 nTPM
placenta: 48 nTPM
pancreas: 41 nTPM

Single-cell type

renal connecting tubule cells: 3,322 nCPM
distal convoluted tubule cells: 2,407 nCPM
renal collecting duct principal cells: 1,811 nCPM
renal collecting duct intercalated cells: 1,627 nCPM
loop of henle epithelial cells: 1,534 nCPM
syncytiotrophoblasts: 1,497 nCPM

Immune cell

memory B-cell: 15 nTPM
naive B-cell: 9.5 nTPM
plasmacytoid DC: 8.2 nTPM
NK-cell: 0.8 nTPM
total PBMC: 0.4 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 62 nTPM
thalamus: 28 nTPM
pons: 20 nTPM
amygdala: 20 nTPM
cerebral cortex: 20 nTPM
medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.05
gnomAD missense Z: -0.22
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COBLL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COBLL1 as an antibody target. Whether an autoantibody or antibody against COBLL1 could matter depends on whether native COBLL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COBLL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COBLL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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